Modeling human trophoblast, the placental epithelium at the maternal fetal interface

M Horii, O Touma, T Bui, MM Parast - Reproduction, 2020 - rep.bioscientifica.com
… the lack of proper modeling systems, the molecular mechanisms of these … models and
tumor-derived trophoblast cell lines, both of which are suboptimal for modeling this unique human

Integrating High-Throughput Approaches and in vitro Human Trophoblast Models to Decipher Mechanisms Underlying Early Human Placenta Development

BK Lee, J Kim - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… While impaired trophoblast differentiation results in pregnancy disorders affecting both
mother and fetus, the molecular mechanisms underlying early human placenta development

[HTML][HTML] Human placental development and function

T Cindrova-Davies, AN Sferruzzi-Perri - Seminars in cell & developmental …, 2022 - Elsevier
… current knowledge of early human placental development, discuss the critical … models of
trophoblast and endometrial stem cells. In addition, we discuss the role of oxygen in placental

In vitro model of human trophoblast in early placentation

D Bačenková, M Trebuňová, D Čížková, R Hudák… - Biomedicines, 2022 - mdpi.com
… The molecular mechanisms involved in placental formation inside the human body along …
There is a similar molecular mechanism to the expression of some key TFs, including CDX2, …

Mechanisms of early placental development in mouse and humans

M Hemberger, CW Hanna, W Dean - Nature Reviews Genetics, 2020 - nature.com
… mouse model and in vitro-derived murine trophoblast stem … into these aspects of placental
development and function, with … to trophoblast differentiation and placenta formation. These …

A comprehensive review of human trophoblast fusion models: recent developments and challenges

X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
… and functionality of placental trophoblasts. In this study, we systematically evaluated the …
placental trophoblast fusion models, providing a comprehensive overview of their development

New era of trophoblast research: integrating morphological and molecular approaches

S Io, E Kondoh, Y Chigusa, K Kawasaki… - Human …, 2020 - academic.oup.com
development of human placenta is crucial. This review elucidates the uniqueness of the
human placenta in early development from the aspect of structural characteristics and molecular

Transcription factor networks in trophoblast development

H Papuchova, PA Latos - Cellular and Molecular Life Sciences, 2022 - Springer
… the three main trophoblast lineages of the human placenta are … stem cells (hTSCs) and
self-organizing trophoblast … to study molecular mechanisms driving trophoblast development and …

Early human trophoblast development: from morphology to function

M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
… The composition of these trophoblast subpopulations is crucial for human placenta development
and alterations are … The key placental cell type involved in all these processes is the …

The TGFβ family in human placental development at the fetal-maternal interface

SM Chuva de Sousa Lopes, MS Alexdottir… - Biomolecules, 2020 - mdpi.com
… that a trophoblast stem cell (TSC) population exists in the early human placenta. However, …
Together with the known sFLT1 and sENG biomarkers of PE, the molecular mechanism is …