… organoids to build functional bio-artificial livers that can be useful for disease modeling, drug
screening… Primary hepatic tumors are mainly hepatocellular carcinoma, cholangiocarcinoma…

… features of the liver such as the bile canaliculi network. In these previously reported liver
organoids, disease modeling is limited to functional aspects of the different hepatic cell types, …

… of tumor organoids for inherent drug resistance of primary liver cancer (PLC) and mechanisms
of acquired drug … HCC organoids perform better than PDX for drug screening. Acquired …

… using hepatoblastoma organoids to complete a drug screen alongside normal liver control
… a high-throughput drug screen that we are pursuing against PDX for various liver tumors, we …

… of liver organoids in disease modelling, drug validation and … both primary liver cancer and
colon cancer liver metastases. … the in vivo liver in disease modelling and drug screening [66]. …

… tumor-derived organoids have a variety of uses, including drug screening in living models
and in vitro drug … pathophysiological conditions are promising for in vitro disease modeling. …

… 2D cell lines offers the opportunity to conduct drug screens and other studies within a context
that more accurately represents the diversity and genetic complexity of human liver cancer. …

… organoid cultures, the gene expression profiles of organoids were compared to those of the
primary … Healthy gallbladder-derived organoid and original tissue were used as controls. The …

… human CRC primary tumor derived organoids in murine spleen to obtain xenografted liver
metastases in murine liver. … Our drug testing results were similar as the published PDX model …

… We adapted HLOs both for high-throughput drug screening in 384-well plates and for
enhanced physiological fidelity in a liver chip system (Emulate Bio) 13 previously used to …