Humoral response to two doses of BNT162b2 vaccination in people with HIV
LD Heftdal, AD Knudsen, SR Hamm… - Journal of internal …, 2022 - Wiley Online Library
Journal of internal medicine, 2022•Wiley Online Library
Abstract Background People with HIV (PWH) are at increased risk of severe COVID‐19. We
aimed to determine humoral responses in PWH and controls who received two doses of
BNT162b2. Methods In 269 PWH and 538 age‐matched controls, we measured IgG and
neutralizing antibodies specific for the receptor‐binding domain of SARS‐CoV‐2 at
baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results IgG antibodies
increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the …
aimed to determine humoral responses in PWH and controls who received two doses of
BNT162b2. Methods In 269 PWH and 538 age‐matched controls, we measured IgG and
neutralizing antibodies specific for the receptor‐binding domain of SARS‐CoV‐2 at
baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results IgG antibodies
increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the …
Background
People with HIV (PWH) are at increased risk of severe COVID‐19. We aimed to determine humoral responses in PWH and controls who received two doses of BNT162b2.
Methods
In 269 PWH and 538 age‐matched controls, we measured IgG and neutralizing antibodies specific for the receptor‐binding domain of SARS‐CoV‐2 at baseline, 3 weeks and 2 months after the first dose of BNT162b2.
Results
IgG antibodies increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the concentrations of IgG antibodies were lower in PWH than that in controls at 3 weeks and 2 months (p = 0.025 and <0.001), respectively. The IgG titres in PWH with a humoral response at 2 months were 77.9% (95% confidence interval [62.5%–97.0%], age‐ and sex‐adjusted p = 0.027) of controls.
Conclusions
Reduced IgG antibody response to vaccination with BNT162b2 was found in PWH, and thus increased awareness of breakthrough infections in PWH is needed.
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