… , which expressed elevated levels of the hyaluronan receptor CD44, and are located primarily
… LMVECs have been demonstrated to promote lung regeneration by producing the matrix …

… TLR-4 protects against oxidant-mediated lung injury by maintaining anti-apoptotic … [75],
promoting alveolar stem cell renewal [33] and epithelial self-defense mechanisms through TLR-4-…

… can promote AT2 proliferation [12, 28]. In contrast, BMP4 signaling inhibits AT2 self-renewal
but promotes AT2 to … For example, Toll-like receptor 4 (TLR4) appears to be required for AT2 …

… are specialized secretory and progenitor cells. AEI … with bound hyaluronan promoting their
survival [50]. Moreover, … cuboidal AEII cells exert their secretory and renewal function mainly in …

… to its capacity to promote cancer stem cell self-renewal. HA … cell surface receptors such
as RHAMM, TLR2, and TLR4 (49), … Failure of alveolar epithelial stem and progenitor cells to …

… Clara cells have anti-inflammatory ability as well as promote bronchial epithelial … However,
AT2s, as facultative progenitor cells of the alveoli, 25 not only have the ability to self-renew, …

… that either promote or deter progenitor cell renewal is … capacity of alveolar progenitor cells
under homeostatic and … but increased cell migration–inducing and hyaluronan-binding protein (…

… mechanisms, such as that of hyaluronic acid (HA), that may … for maintaining tissue structure,
promoting cell survival, and … TLR4 endocytosis in alveolar macrophages, limiting TLR4 …

… to be kept low by turnover by alveolar macrophages (AM) which … -tissue-derived mesenchymal
stem cells was shown to reduce … Modified high-molecular-weight hyaluronan promotes …

… to be kept low by turnover by alveolar macrophages (AM) which … -tissue-derived mesenchymal
stem cells was shown to reduce … Modified high-molecular-weight hyaluronan promotes …