Modified nucleic acids: Expanding the capabilities of functional oligonucleotides
S Ochoa, VT Milam - Molecules, 2020 - mdpi.com
… It is important to note that incorporation of modifications within the binding motifs of aptamer
… In addition to serving as the sole hybridization partner for a natural oligonucleotide, …
… In addition to serving as the sole hybridization partner for a natural oligonucleotide, …
Nucleic acids triple helices
R Eritja - Nucleic Acids Chemistry. Modifications and Conjugates …, 2021 - degruyter.com
… triplex I motif or parallel triplex, an oligonucleotide made of cyto… or PNA openers that facilitates
hybridization by binding to the … stable oligonucleotide-directed triple helix formation at the …
hybridization by binding to the … stable oligonucleotide-directed triple helix formation at the …
Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA
F Podlaski, S Cornwell, K Wong, B McKittrick… - ACS …, 2023 - ACS Publications
… hybridization studies reveal for the first time that this type of cationic/amino-alkyl base-modified
PNA has favorable hybridization properties … affinity for oligonucleotide hybridization at 37 …
PNA has favorable hybridization properties … affinity for oligonucleotide hybridization at 37 …
Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids
Y Mikame, A Yamayoshi - Pharmaceutics, 2023 - mdpi.com
… at the promotor region can induce either inhibition or activation effect depending on the triplex
motif (… 8), which permits the donor DNA to hybridize the target DNA. Finally, the homology-…
motif (… 8), which permits the donor DNA to hybridize the target DNA. Finally, the homology-…
Targeting DNA with triplexes
KR Fox - Handbook of Chemical Biology of Nucleic Acids, 2023 - Springer
… Triple helical nucleic acids are generated by the binding of a third oligonucleotide strand within
the … available for complementary DNA hybridization, linking the component tiles together. …
the … available for complementary DNA hybridization, linking the component tiles together. …
Recent progress in non-native nucleic acid modifications
… for introducing these modifications into oligonucleotides. … to a broad variety of base-modified
nucleoside analogues. … recognition, folding, and hybridization properties. A treatment with a …
nucleoside analogues. … recognition, folding, and hybridization properties. A treatment with a …
Synthesis and studies of modified DNA:(i) development of DNA targeting molecular scissors and (ii) competitive enzymatic incorporation of base-modified nucleotides
A Panattoni - 2020 - dspace.cuni.cz
… The hybridization of all the synthesized TFOs with a target DNA duplex was … oligonucleotides
able to bind a oligopurine segment of a DNA duplex with formation of a DNA triple helix (H-…
able to bind a oligopurine segment of a DNA duplex with formation of a DNA triple helix (H-…
Chemical Synthesis of New Modified Nucleotides Towards Improved Antisense Oligonucleotide Drugs
MB Danielsen - 2022 - portal.findresearcher.sdu.dk
… This results in the formation of three triplex motifs, depending on their base composition and
… This is different from xylo-LNA, which had a negative effect on the hybridization properties …
… This is different from xylo-LNA, which had a negative effect on the hybridization properties …
3 Synthesis of oligonucleotides carrying modified bases for DNA and protein recognition
… to degradation by nucleases while maintaining similar hybridization properties than
unmodified oligonucleotides [210]. The addition of a syn -norspermidine group at position 5 of 2-…
unmodified oligonucleotides [210]. The addition of a syn -norspermidine group at position 5 of 2-…
The medicinal chemistry of artificial nucleic acids and therapeutic oligonucleotides
… The PCR test requires appropriately designed primer oligonucleotides, which can hybridize
… motif is obtained by oxidizing the corresponding ribonucleoside derivative into a 2′,3′-…
… motif is obtained by oxidizing the corresponding ribonucleoside derivative into a 2′,3′-…