Neuroprotective effects of adenosine A1 receptor signaling on cognitive impairment induced by chronic intermittent hypoxia in mice

Y Zhang, H Cao, X Qiu, D Xu, Y Chen… - Frontiers in cellular …, 2020 - frontiersin.org
… In contrast, activation of adenosine A1R signaling reduced morphological changes and …
The 8-arm (4-arm baited) radial maze test in mice without or with treatments from air control …

Use of knockout mice to explore CNS effects of adenosine

CR Lopes, VS Lourenco, AR Tome, RA Cunha… - Biochemical …, 2021 - Elsevier
mice lacked the adaptive decrease of neuronal activity upon … , with a moderate heat
hyperalgesia without alterations of … by A 2A R-KO mice was the robust neuroprotection to acute …

Targeting adenosine receptors: a potential pharmacological avenue for acute and chronic pain

F Vincenzi, S Pasquini, PA Borea, K Varani - International Journal of …, 2020 - mdpi.com
… demand, hypoxia, … decreased hyperalgesia through the involvement of peripheral and
central A 1 ARs [26]. In another report, intrathecal adenosine injection inhibited hyperalgesia in …

Adenosine receptors as potential therapeutic analgesic targets

M Haddad, F Cherchi, M Alsalem… - International Journal of …, 2023 - mdpi.com
… by it adenosine and the increase in thermal hyperalgesia in … As a result, mice lacking the A
2A AR responded less strongly … like hypoxia/ischemia and inflammation, where adenosine is …

Adenosine-related mechanisms in non-adenosine receptor drugs

KA Jacobson, ML Reitman - Cells, 2020 - mdpi.com
… , CDB (100 µM) reduced hypoxic ischemic brain damage by … Its anti-hyperalgesic affect
in mice was antagonized by the … An antinociceptive and neuroprotective traditional Chinese …

Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms

HS Province, C Xiao, AS Mogul, A Sahoo… - Plos one, 2020 - journals.plos.org
… We generated mice lacking neuronal adenosine A 1 receptors (… , extracellular adenosine
levels are typically low [2] and … injury after neonatal hypoxia or cardiopulmonary resuscitation [7]…

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors

M Frinchi, V Verdi, F Plescia, F Ciruela, M Grillo… - International Journal of …, 2020 - mdpi.com
… three anxiety-related paradigms in rats. … reduces the effects of A 1 R activation [21]. In
addition, positive allosteric modulation of A 1 R produces anxiolytic-like effects [32] or mice lacking

Neurobehavioral and neuroprotector effects of caffeine in animal models

D Villanueva-García, D Mota-Rojas… - Journal of Animal …, 2020 - app.periodikos.com.br
hypoxic lesion, produced neuroprotection, immunomodulation, and partial functional recovery.
Improvement on the open-field behavioral test reduced … in mice lacking adenosine A1 and…

Adenosine and ketogenic treatments

DN Ruskin, M Kawamura Jr… - … of Caffeine and Adenosine …, 2020 - liebertpub.com
lowered glucose in the brain. More research is needed to investigate the importance of
adenosine in the antiepileptogenic and neuroprotective … Ischemic or hypoxic events can lead to …

Adenosine receptors in neuropsychiatric disorders: fine regulators of neurotransmission and potential therapeutic targets

S Pasquini, C Contri, S Merighi, S Gessi… - International journal of …, 2022 - mdpi.com
… In the case of cellular stress such as injury, hypoxia, neurodegeneration, neuroinflammation…
be associated with a decreased risk of AD [152]. The cognitive and neuroprotective effects of …