Analysis of flow resistance in the pulmonary arterial circulation: Implications for hypoxic pulmonary vasoconstriction

DW Johnson, TK Roy… - Journal of Applied …, 2021 - journals.physiology.org
… have been proposed to contribute to vasoconstriction, including … cells and are not considered
to be major contributors to HPV. … of heterogeneity in network structure and flows does not

[HTML][HTML] The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery

M Licker, A Hagerman, A Jeleff, R Schorer… - Saudi Journal of …, 2021 - journals.lww.com
… septa further contribute to reduce capillary blood flow and … (nitric oxide [NO], prostacyclin [PGI
2 ]) and vasoconstrictors (… patients has been attributed to greater heterogeneity in V/Q ratios …

[HTML][HTML] Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome

M Gierhardt, O Pak, D Walmrath… - … Respiratory Review, 2021 - Eur Respiratory Soc
… In a recent study using lung protective ventilation with PEEP, a heterogeneous … of blood
flow to poorly ventilated areas, and impaired hypoxic pulmonary vasoconstriction can lead to V/Q …

[HTML][HTML] Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching

AD Marquis, F Jezek, DJ Pinsky… - PLoS Computational …, 2021 - journals.plos.org
blood flow heterogeneity via arterial spin labeling. Their results show that under mild hyperoxia
that there was little change in the distribution of blood flow … a sheet flow model would add

The pulmonary vasculature

SR Hopkins, MK Stickland - … in Respiratory and Critical Care …, 2023 - thieme-connect.com
Hypoxic pulmonary vasoconstriction is one such important … There are several factors that
contribute to this uncertainty … have observed substantial blood flow heterogeneity within an …

Functional implications of microvascular heterogeneity for oxygen uptake and utilization

TK Roy, TW Secomb - Physiological Reports, 2022 - Wiley Online Library
lead to intrinsic heterogeneity in the microcirculation. Arrows indicate directions of blood
flow. … demand, such as exercise, hypoxic pulmonary vasoconstriction (HPV) acts to improve …

Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung

PP Jain, S Hosokawa, M Xiong… - Pulmonary …, 2020 - journals.sagepub.com
hypoxic pulmonary vasoconstriction. These data indicate that Ca 2+ influx in pulmonary
arterial … 2+ entry pathways all contribute to initiation of hypoxic pulmonary vasoconstriction. The …

[HTML][HTML] The impact of heterogeneity of the air-blood barrier on control of lung extravascular water and alveolar gas exchange

G Miserocchi - Frontiers in Network Physiology, 2023 - frontiersin.org
… of the macromolecular structure of lung tissue. This review, … the heterogeneity in morphology,
mechanical features and perfusion of the terminal respiratory units might impact on lung

Anesthesia, Mechanical Ventilation, and Hypoxic Pulmonary Vasoconstriction

A Hagerman, M Licker - Cohen's Comprehensive Thoracic Anesthesia, 2022 - Elsevier
… septa slightly contribute to reduce capillary blood flow and to … (nitric oxide [NO], prostacyclin
[PGI2]) and vasoconstrictors (… was paralleled by heterogeneous regional hypoxia and V/Q …

[HTML][HTML] Dysregulation of the nitric oxide/Dimethylarginine pathway in hypoxic pulmonary vasoconstriction—molecular mechanisms and clinical significance

J Hannemann, R Böger - Frontiers in Medicine, 2022 - frontiersin.org
… failure, and contributing to … does not differ between systemic and pulmonary arteries.
Therefore, this mechanism cannot explain the heterogeneous response to hypoxia (vasoconstriction