… further, BAL cells from sarcoidosis patients can also release bioactive IL-12 and IL-18 which
are important Th1 cytokines and able to synergistically induce IFN-γ production (20). There …

… other innate receptors that stimulate local Th1 responses [Citation83]. SAA may
contribute to … IL-18 upregulates the Th1 immune response via IL-2, IL-12 and IFN-γ [Citation140,Citation…

… Once in the lungs, CD4+ T cells release cytokines (IFN-γ, TNFα, IL-12, and IL-18) which
stimulate … of how fibrosis can begin in a sarcoidosis pulmonary milieu characterized by elevated …

… of interleukin (IL)-1β and IL-18 into their active forms [11,12]. … interferon (IFN)γ and produce
IL-12 and tumor necrosis factor (TNF)… CD4 + T-cells from pulmonary sarcoidosis patients have …

… DCs by producing potent inflammatory mediators, such as IL-12 and IL-18 contribute to
Th1 polarization, activation, and more IFN-γ production, resulting in enhanced antigen …

… .1 both produce IFN-γ, there is increasing evidence that most of IFN-γ, production is sourced
from … CCL18 in turn stimulates collagen production by fibroblasts starting a positive feedback …

… spontaneously express IL-2 receptors and release interferon γ (IFN-γ), TNF-α, and IL-2 (5). …
with active pulmonary sarcoidosis (61–65). IL-23 is a member of the IL-12 cytokine family …

… 2, IL-12, IL-18, TNF-α, and IFN-γ. According to a report, miRNA-34a suppresses the expression
of sirtuin 1 (SIRT-1) and stimulates the secretion of IFN-γ [… -29a and increased IFN-γ have …

… ,1 with pulmonary involvement being the most common.… , macrophages produce interleukin
(IL)- 6, IL- 12, IL- 18, IL- 23, … The authors suggested that IFN- γ is a key driver of sarcoidosis …

… to TCR stimulation by secretion of IL-2 and IFN-γ that … IL-12 and IL-18 production or reducing
the TH1 response via … the inflamed lungs and become exposed to high IL-12 and/or IFN-γ …