Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice

A Teijeiro, A Garrido, A Ferre, C Perna, N Djouder - Nature Metabolism, 2021 - nature.com
… of IL-17 receptor A (Il17ra), suppresses diet-induced obesity (DIO… to control appetite, glucose
homeostasis, insulin sensitivity … the adipocyte genetic landscape, and promotes obesity and …

[PDF][PDF] A study of the association between IL-17 and HOMA-IR in Iraqi type 2 diabetic patients

KM Abbas, SFT Alaaraji, RS Al–Shawk - 2020 - iasj.net
… In conclusion, IL-17 seems to play a significant role as a risk factor for the development of …
T2DM patients compared with controls. From our results, we can conclude that obesity is a risk …

[HTML][HTML] Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17

R Bergin, D Kinlen, N Kedia-Mehta, E Hayes… - Diabetologia, 2022 - Springer
IL-17 on insulin-mediated glucose intake into HSMCs, and demonstrated that IL-17 strongly
inhibited glucose … Finally, we demonstrated that IL-17 inhibits the downstream signalling of …

IL-17A contributes to propagation of inflammation but does not impair adipogenesis and/or insulin response, in adipose tissue of obese individuals

J Pestel, M Chehimi, M Bonhomme, M Robert, H Vidal… - Cytokine, 2020 - Elsevier
… Both in human and rodent models, obesity has been shown to promote expansion of IL-17-…
-obesity (DIO) murine model, Winer et al. have shown selective activation of splenic IL-17 + …

[HTML][HTML] Adipose tissue immunomodulation and Treg/Th17 imbalance in the impaired glucose metabolism of children with obesity

S Croce, MA Avanzini, C Regalbuto, E Cordaro, F Vinci… - Children, 2021 - mdpi.com
… Moreover in obese subjects, it is shown that an IL-17 decrease promotes adipogenesis [93]. …
blood of overweight/obese patients with impaired glucose regulation or T2DM compared to …

[HTML][HTML] Is interleukin 17 (IL-17) expression A common point in the pathogenesis of depression and obesity?

K Bliźniewska-Kowalska, B Szewczyk… - Journal of clinical …, 2020 - mdpi.com
… and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed
that BMI does not affect IL-17 … the effects of IL-17 inhibition on adipose tissue and vice versa. …

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

B Hu, C Jin, X Zeng, JM Resch, MP Jedrychowski… - Nature, 2020 - nature.com
… TGFβ1 in parenchymal cells via the IL-17 receptor C (IL-17RC)… to thermogenesis, we generated
adipocyte-specific IL-17RC-… to diet-induced obesity and glucose tolerance. Indeed, when …

[HTML][HTML] MicroRNAs of the miR-17~ 92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

X Zhang, J Liu, L Wu, X Hu - Elife, 2020 - elifesciences.org
… As obesity is often associated with insulin resistance, we first examined the glucose
homeostasis in TKO and WT mice with glucose tolerance test (GTT) and found that TKO mice …

[HTML][HTML] Contribution of IL-17 in steroid hyporesponsiveness in obese asthmatics through dysregulation of glucocorticoid receptors α and β

S Al Heialy, M Gaudet, RK Ramakrishnan… - Frontiers in …, 2020 - frontiersin.org
… of IL-17 cytokines in steroid hyporesponsiveness in obese asthmatics. We stimulated lean
and obese … This data suggests that IL-17 may modulate adipocyte responses to steroids and …

[HTML][HTML] Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes

X Hong, Y Zhou, Z Zhu, Y Li, Z Li, Y Zhang, X Hu… - Environment …, 2023 - Elsevier
… level of IL-17 is increased in obese people, and anti-IL-17 antibody therapy can alleviate the
obesity (… Previous study has shown that IL-17 negatively regulated fat formation and glucose