… are lost under obesogenic conditions due to downregulation of … IL-21 or T-cell-specific loss
of STAT3 rescued the VAT-Treg … , it is important to determine how type-I IFNs affect VAT Tregs …

… stimulates glucose and fatty acid oxidation and lipolysis [70]. … that IL-21 exerts negative
regulation on Treg activity, favoring … and in Treg/Th17 imbalance influencing metabolic responses…

… expression of IL-21 and IL-10. Interleukin 21 negatively regulates regulatory T-cells in GWAT
… Investigating the role of IL-21 in modulating regulatory T-cells or other immune cell subsets …

… IL-25 increases lipolysis and free fatty acids through adipose … IL-21 expression in T-cells is
modulated by IL-21 in autocrine … repress differentiation of inducible Tregs as demonstrated in …

… Another study showed that high levels of IFN-I induced apoptosis of regulatory T cells (Tregs…
IL-21 has been reported to be a negative regulator of IRF4, and IL-21-deficient mice …

… /Treg cells, Tfr cells do not produce the helper cytokines IL-21 … Moreover, c-Maf may affect
the differentiation of Tfr cells via … IL-21 is a negative regulator of Tfr cell development. High …

… IL-21 is a major negative regulator of 648 IRF4-dependent lipolysis affecting Tregs in
adipose tissue and systemic insulin 649 sensitivity. Diabetes. 2014;63(6):2086-2096. …

… , and then proceed to explore how these events affects 2 key processes that are critical for …
in turn enhanced thermogenesis, ß-oxidation, lipolysis and adipocyte differentiation94. Similar …

… , which affect pancreatic β cells and participate in immune regulation … immune regulation by
increasing the Treg frequency may be … Treg proliferation and function enhanced the adipose …

… regulation of immune cell development and function 13,14 . It is also a transcriptional regulator
of lipolytic genes in adipose … in regulating thermogenesis in brown adipose tissue (BAT) …