Combined and distinct roles of Agr proteins in Clostridioides difficile 630 sporulation, motility, and toxin production

UKB Ahmed, TM Shadid, JL Larabee, JD Ballard - MBio, 2020 - Am Soc Microbiol
… difficile senses growth conditions to regulate toxin expression and … Agr1, the focus of our
study, is a two-gene locus encoding … factors might be impacted by intracellular AgrD1, we were …

Good gone bad: one toxin away from disease for Bacteroides fragilis

E Valguarnera, JB Wardenburg - Journal of molecular biology, 2020 - Elsevier
… the active C-terminal domain into the extracellular milieu [74,75]. … Studies on the genetic
locus that encodes BFT have been … controls transcription [94]. A key mechanism for control of …

Pathogenicity and virulence of Clostridium perfringens

I Mehdizadeh Gohari, M A. Navarro, J Li, A Shrestha… - Virulence, 2021 - Taylor & Francis
… perfringens toxins is highly regulated via processes involving … of toxins and extracellular
degradative enzymes produced by … loci on large tcp-conjugative plasmids suggests that the toxin

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

AM Geller, I Pollin, D Zlotkin, A Danov… - Nature …, 2021 - nature.com
… we identify eCIS loci in 1,249 bacterial and archaeal genomes and reveal an enrichment of
these loci … , Tse2 50 , as a positive control, and two negative controls: a monomeric enhanced …

Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

R Bonelli, VE Jackson, A Prasad, JE Munro… - Communications …, 2021 - nature.com
… We aimed to: (1) confirm the originally reported genetic loci, and assess the strength of …
genotype data from that study and identified as heterozygotes two healthy controls and seven age…

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
… the production of extracellular toxins and enzymes (244… that Rot can potentially regulate all
four protease loci, but the degree … The idea is to identify molecules that specifically target the …

In vitro and in vivo biofilm forming Vibrio spp: a significant threat in aquaculture

M Arunkumar, F LewisOscar, N Thajuddin… - Process …, 2020 - Elsevier
… with the self-production of extracellular polysaccharides (EPS). … aquaculture have been
identified, analyzed and documented … vulnificus, wcr locus regulates the EPS production and the …

Biological functions of type II toxin-antitoxin systems in bacteria

M Kamruzzaman, AY Wu, JR Iredell - Microorganisms, 2021 - mdpi.com
… biofilm production presumably by releasing extracellular DNA (… prophage but also regulates
the production of active phage … Later, the hipAB locus was identified as a TA system [133,134…

Pathogenicity assessment of Shiga toxin-producing Escherichia coli strains isolated from wild birds in a major agricultural region in California

MQ Carter, B Quiñones, N Laniohan… - Frontiers in …, 2023 - frontiersin.org
… mobile genetic elements (MGEs), including prophages for Shiga toxin expression, the locus
of … % amino acids sequence identity while the Pic encoded by the second plasmid (locus tag: …

Identifying a molecular mechanism that imparts species-specific toxicity to YoeB toxins

JR Ames, J McGillick, T Murphy, E Reddem… - Frontiers in …, 2020 - frontiersin.org
… chimera gains toxicity to Ec cells and lessens toxicity to At cells. … helix sequence is less toxic
to Ec and gains toxicity to At cultures. … , and thus controls growth inhibition and YoeB toxicity. …