The transcriptional repressor REV-ERB as a novel target for disease

A Uriz-Huarte, A Date, H Ang, S Ali, HJM Brady… - Bioorganic & Medicinal …, 2020 - Elsevier
… REV-ERBα and REV-ERBβ share almost complete identity in their DNA binding domains (…
The apolipoprotein A1 (ApoA1) and apolipoprotein C3 (ApoC3) genes also play a major role …

Integrated structural modeling of full-length LRH-1 reveals inter-domain interactions contribute to receptor structure and function

CD Seacrist, G Kuenze, RM Hoffmann, BE Moeller… - Structure, 2020 - cell.com
Liver receptor homolog-1 (LRH-1; NR5A2) is a nuclear receptor that regulates a diverse …
binding, hydrophobic ligand binding, and co-regulator binding, far less is known about how …

[HTML][HTML] Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells

Q Zhao, Y Lan, X Shi, X Sun - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
… We identified the biological effects of lncRNA FTX in ECs. … encoded by genes including C3,
chromobox protein homolog 1, … into liver cells, suggesting that the FGD6 gene might play a …

Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome

S Akter, H Akhter, HS Chaudhury, MDH Rahman… - …, 2022 - Wiley Online Library
… The increased triglycerides in the liver and … genetic variants have been discovered in
relation to polygenic obesity, 130, 131 and 32 BMI- and 13 WHR-associated loci were identified in …

The ABCs of sterol transport

AM Plummer, AT Culbertson… - Annual Review of …, 2021 - annualreviews.org
… efflux to the extracellular apolipoprotein AI protein (apoA-I) to … ABCA1 was initially identified
from murine macrophages and … liver receptor homolog 1 (124). In addition, agonists for either …

MicroRNAs as master regulators of atherosclerosis: from pathogenesis to novel therapeutic options

MR Hosen, PR Goody, A Zietzer… - Antioxidants & Redox …, 2020 - liebertpub.com
… , are now emerging as novel regulators of intercellular … human protein-coding genes have
been identified as being … of v-ets, erythroblastosis virus E26 oncogene homolog 1 (Ets-1), a …

Dietary bile acids regulate the hepatic lipid homeostasis in tiger puffer fed normal or high-lipid diets

Z Liao, B Sun, Q Zhang, L Jia, Y Wei, M Liang, H Xu - Aquaculture, 2020 - Elsevier
… expression of genes related to lipid transport in the liver of experimental fish. For each … of
other lipid metabolism related genes in the liver of experimental fish. For each gene, values (…

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes

M Aghadi, R Elgendy, EM Abdelalim - Cell Death & Disease, 2022 - nature.com
… We identified 2608 and 1122 differentially expressed genes (… liver does not change the
expression levels of liver genes [19]… of developmental genes is significantly altered in mouse liver

Dietary taurine stimulates the hepatic biosynthesis of both bile acids and cholesterol in the marine teleost, tiger puffer (Takifugu rubripes)

H Xu, Q Zhang, SK Kim, Z Liao, Y Wei, B Sun… - British Journal of …, 2020 - cambridge.org
… in the present study at the gene transcription level. Results of the … bile acids at the current
detection level. Only three conjugated … receptor homolog-1, was involved in the regulation of …

l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice

Y Wang, J Zhao, Q Li, J Liu, Y Sun, K Zhang, M Fan… - Nutrition & …, 2022 - Springer
gene and protein expressions in the liver and small intestine were analyzed. … while ABCA1
promotes cholesterol flow to apolipoprotein A1 [37]. Expressions of … Liver receptor homolog-1