[图书][B] Reexamination of G protein activation model by non-dissociable Gα-Gβ fusion proteins

W Liu - 2021 - search.proquest.com
… constitute the trimeric G protein complex: an α subunit (Gα) … Gαq subunits: Gαq, Gα11, Gα14
and Gα16 (named as Gα15 … conformational changes occur upon GTP binding. Among them, …

[HTML][HTML] Mammalian type opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response

K Sato, T Yamashita, H Ohuchi - Journal of Biological Chemistry, 2023 - ASBMB
… major Gα classes, Gαq, Gα11, Gα14, and Gα15 in the Gq class … FISH revealed co-expression
of genes encoding Opn5m and … Among them, the α subunit has a guanosine diphosphate/…

[PDF][PDF] Receptor-mediated activation and pharmacological inhibition of heterotrimeric G proteins

JH Voß - 2022 - d-nb.info
… , the Gαq/11 family includes the Gαq, Gα11, Gα14, and Gα15 … -dependent protein, but GTP
binding to the naïve Gαq protein … the yield of recombinantly expressed Gαq proteins from non-…

[HTML][HTML] 12/13 signaling in metabolic diseases

YM Yang, DS Kuen, Y Chung, H Kurose… - Experimental & Molecular …, 2020 - nature.com
… Thus, the phosphorylation-defective mutant of 15 is not … Gα q and inhibits GTP binding
and Gαq-mediated signaling, … Inhibition of transducin α subunit (Tα) translocation from the …

[HTML][HTML] OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

AC Keen, MH Pedersen, L Lemel, DJ Scott… - Communications …, 2022 - nature.com
… G proteins and that expression of the catalytic S1 subunit is sufficient for this inhibition. We
identify … OZITX pre-treatment did not inhibit the activation of Gα q , Gα 11 or 15 although Gα …

[HTML][HTML] Agonist-selective activation of individual G-proteins by muscarinic receptors

D Nelic, N Chetverikov, M Hochmalová, C Diaz… - Scientific Reports, 2024 - nature.com
protein inserts the C-terminus of the α-subunit. Subsequently, G-… expressing M1, and a
marginal response in CHO expressing … of G proteins: Gαq, Gα11, Gα14 and Gα15 upon agonist …

Heterotrimeric G protein Α-subunits-structures, peptide-derived inhibitors, and mechanisms

JH Voss, CE Müller - Current Medicinal Chemistry, 2022 - ingentaconnect.com
… in the human species sharing a common protein architecture… GDP-bound Gαq protein (protein
data bank-identification (PDB-… inactive at Gα15/16 and at the other Gα protein subfamilies. …

Activators of G‐Protein Signaling in the Normal and Diseased Kidney

F Park - GPCRs as Therapeutic Targets, 2022 - Wiley Online Library
… transcription factors [202, 203] and Gα15/α16 subunits [204]. … The G protein α subunit variant
XLαs promotes inositol 1,4,5-… the β subunit of GTP-binding regulatory proteins identified by …

… At-CLO4 in Regulation of Heterotrimeric G Protein Complex in Arabidopsis thaliana and Characterization of Members of the Extra-Large G Protein Family in Triticeae

MR Ehdaeivand - 2020 - spectrum.library.concordia.ca
… were identified and characterized for expression patterns. … GPA1, the α subunit of the
heterotrimeric G protein complex, … protein complex in Arabidopsis, the Extra Large GTP binding

Agonist-selective activation of individual G-proteins by muscarinic receptors

A Janouskova-Randakova, D Nelic, N Chetverikov… - 2024 - researchsquare.com
… which the G-protein inserts the C-terminus of the α-subunit. 44 … M1, and a 180 marginal
response in CHO expressing M3 … class of G proteins: Gαq, Gα11, Gα14 and Gα15 upon agonist …