… search of PubMed and Google Scholar was performed using key words including ‘mast
cells’, ‘arthritis’, ‘inflammation’, and ‘mast cell activation’ for the period between 2000 and 2022. …

… to promote inflammation in osteoarthritis and skin [106,108]. Similarly, the pro-inflammatory …
Most of these enzymes are potential targets for inhibiting the IgE-mediated activation of MCs …

… specific to mast cells and inflammation that drive the cell … a significant upregulation of mast
cells specific genes such as … -stained active mast cells were seen populated in cartilage, …

… cartilage degeneration, synovial inflammation and pain worsening in an OA mouse model,
suggesting that OA flares may be partly due to MC activation [… inhibition of IgE-mediated FceRI …

… It may be involved in anaphylactoid non-IgE–mediated … activates synovial fibroblasts and
enhances their capacity to produce proteases capable of degrading the structure of cartilage …

… mast cell”; “rheumatoid arthritis AND mast cell”; “gout AND … system but cannot initiate
IgE-mediated allergic responses. … progressive destruction of joint structures, including cartilage …

… Our novel OA flare mice model showed articular cartilage degeneration together with MC
infiltration at histological level, acute exacerbation of pain behavior, and increased gene …

… histamine and H 1 R are both involved in the release of pro-inflammatory mediators and …
DMM mouse model of OA and demonstrated that it protects against cartilage degeneration. …

… the presence of Mast Cells (MCs) in synovial samples from gleno-humeral osteoarthritis (OA…
-CD117 antibodies, to detect respectively endothelial cells and MCs at 40x magnification. …

… of bone and cartilage 5 . T … of MRGPRX2 36 , which explains mast cell activation in many
non-IgE-mediated diseases, we speculated that synovial mast cell activation in RA patients was …