Imaging-based diagnostic and therapeutic strategies for prostate cancer in the coming decades
AR Padhani, IG Schoots - Radiology, 2023 - pubs.rsna.org
Radiology, 2023•pubs.rsna.org
Prostatectomy data suggest that a substantial proportion have higher-grade disease; 30%–
50% of patients undergo treatment in the first 5 years despite< 3% 15-to 20-year mortality;
although overall survival is not compromised, the prevalence of metastases is higher in AS
cohorts compared with surgery and RT cohorts 10%–19% of patients have lower-risk
disease that is suitable for initial AS; unfavorable subgroup has a higher prevalence of nodal
disease that would benefit from nodal surgery or RT and hormonal therapy; poor local …
50% of patients undergo treatment in the first 5 years despite< 3% 15-to 20-year mortality;
although overall survival is not compromised, the prevalence of metastases is higher in AS
cohorts compared with surgery and RT cohorts 10%–19% of patients have lower-risk
disease that is suitable for initial AS; unfavorable subgroup has a higher prevalence of nodal
disease that would benefit from nodal surgery or RT and hormonal therapy; poor local …
Prostatectomy data suggest that a substantial proportion have higher-grade disease; 30%–50% of patients undergo treatment in the first 5 years despite< 3% 15-to 20-year mortality; although overall survival is not compromised, the prevalence of metastases is higher in AS cohorts compared with surgery and RT cohorts
10%–19% of patients have lower-risk disease that is suitable for initial AS; unfavorable subgroup has a higher prevalence of nodal disease that would benefit from nodal surgery or RT and hormonal therapy; poor local staging accuracy results in positive resection margins; 30% of patients undergoing surgery have undetected nodal disease
10%–15% of new diagnoses; 50% with the current standard of care (RT or RP without planned adjuvant therapy) are at risk for death, indicating poor local staging accuracy; poor detection of metastatic disease (present in 30%–50%) undetected in 10%–20% at conventional imaging
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