… in vivo and in vitro, and explored the underlying mechanisms. Yeast extract-induced
hyperuricemia animal model as well as hypoxanthine and xanthine oxidase (XOD) co-induced high …

… seems to be a major underlying mechanism for hyperuricemia-induced … The xanthine
oxidoreductase (XOR) is the key and rate-… cell homeostasis via two main signaling pathways: (1) …

… phosphate oxidase (NADPH oxidase) and xanthine oxidase … in L-arginine availability
for nitric oxide synthase (NOS) and … as an important mechanism underlying decreased NO …

… imbalances in the oxidative metabolism as “final common … chain, xanthine oxidase, NADPH
oxidases and uncoupled … negatively regulate the insulin signaling pathway and cause insulin …

… subcellular localization and signaling pathways in the cardiac … come from alternative sources
such as xanthine oxidase, … plaque is commonly the underlying mechanism of an MI. Thus, …

… Thus, nitrite will not accumulate and XOR will try to keep a balance between N-oxides within
muscle prioritizing high nitrate levels rather nitrite within tissue. (Right) Disease conditions …

… oxygen species (ROS) and nitric oxide ·NO formation. We … We speculate that this change
in the balance of activity of the … the current equipoise underlying the perceived importance of …

… NO production by endothelial nitric oxide synthase (eNOS) … (deoxyHb/deoxyMb), and
xanthine oxidase (XO) at the time in … The underlying mechanisms of these age-related disorders …

… underlying this process and particularly, the underlying cross-… , likely enrolling diverse
signaling pathways that reflect the … (eg, hemoglobin, xanthine oxidoreductase, and cytochrome …

… also produce nitric oxide, a cardiovascular protective molecule. Overproduction of nitric oxide
… The underlying inflammatory state that is maintained by chronic hyperuricemia (6.8 mg/dl) …