Immunity to fungi in the lung

LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
… antifungal immunity. We emphasize the role of different anatomic sites and cellular crosstalk
in maintaining sterilizing anti-fungal immunity in the lung and in the pathogenesis of fungus-…

The epithelial cell types and their multi-phased defenses against fungi and other pathogens

K Roe - Clinica Chimica Acta, 2024 - Elsevier
… to epithelial tissue immune defenses against pathogens, including fungal pathogens,
which … tract, including the lung alveoli, can have daily exposures to fungal, viral or bacterial …

Respiratory microbiome and epithelial interactions shape immunity in the lungs

R Invernizzi, CM Lloyd, PL Molyneaux - Immunology, 2020 - Wiley Online Library
… the lung mycobiome compared with the bacterial microbiome, in recent years specific fungi
have … It has also been shown that commensal fungi can affect the immune system and also …

Immunity to invasive fungal diseases

A Casadevall - Annual review of immunology, 2022 - annualreviews.org
… Although at the time of this writing the pathogenesis of fungal pneumonia in lungs damaged
… with scarred lung tissue, which has reduced capacity to clear inhaled fungal spores. Prior to …

Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
… , aspergillosis is a signature infection of chronic granulomatous disease 9 , which highlights
the importance of ROS generation in maintaining sterilizing lung immunity (Table 2). …

Epithelial responses to fungal pathogens

KAM Mills, MA Aufiero, TM Hohl - Current Opinion in Microbiology, 2024 - Elsevier
… Deletion of Il1r1 in AT2s results in an elevated lung fungal … IKK2 have decreased lung function,
delayed fungal clearance, and … signaling in both innate and adaptive antifungal immunity. …

Opportunistic bacterial, viral and fungal infections of the lung

RJ José, JN Periselneris, JS Brown - Medicine, 2020 - Elsevier
… with specific immune defects that increase the risk of opportunistic lung infections (eg
tumour necrosis factor-α inhibitors and risk of mycobacterial disease, endemic fungi and …

T cell antifungal immunity and the role of C-type lectin receptors

EA Speakman, IM Dambuza, F Salazar, GD Brown - Trends in immunology, 2020 - cell.com
immune system. This is underscored by the increased susceptibility to fungal infections that
is associated with loss of immune … of invasive and noninvasive fungal infections such as …

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

S Feys, SM Gonçalves, M Khan, S Choi… - The Lancet …, 2022 - thelancet.com
… These viral–fungal coinfections are difficult to diagnose and are associated with increased
… We aimed to explore the role of lung epithelial and myeloid innate immunity in patients with …

Gut microbiota modulation as a potential target for the treatment of lung infections

CS Cruz, MF Ricci, AT Vieira - Frontiers in Pharmacology, 2021 - frontiersin.org
… for preventing and treating lung infections caused by bacteria, viruses, fungi, and parasites.
… The immune responses in the gut-lung axis depend on the balance of microbiota composition…