… In fact, artificially inducing premature transcriptional arrest at an Ig locus through targeted
insertion of a transcription termination element leads to enhanced hypermutation in the …

… DNA lesions into gene mutation or recombination events with common and unique features.
Here we focus on antibody class switch recombination (… of damaged base to DNA double-…

… Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat
Rev … impaired immunoglobulin classswitch recombination. Nat Immunol. 4(10):1023-1028. …

… antibody molecules. Of note, AID can potentially target all transcriptionally active genes and
induces … ’s ability to induce CSR, we envision that increased IgG antibody responses against …

… induced cytidine deaminase (AID) inflicts DNA damage at immunoglobulin genes to
initiate class switch recombination … DNA lesions at AID target loci in order to model AID-induced …

… Three DNA damage-induced phosphorylation clusters on DNA-… is likely due to AID targeting,
rather than differences in … suggest that another mechanism beyond the loss of DNA-PKcs …

… Bottom: Schematic representation of class switch recombination (CSR). After B cells are …
AID is induced in activated B cells and targets S regions undergoing GLT expression to …

… (CSR) via double-strand DNA breaks (DSB) and synapse of Sμ … Here we find that induction
of IgD CSR downregulates … in mediating a specific IgD antibody response, we immunized …

… as mandatory for class switch recombination (CSR), and this … and nearest activation-induced
deaminase (AID) target sites. … Beyond G1, RPA associates with unrepaired ends in an ATM-…

… induction of Activation-induced cytidine deaminase (AID) and the initiation of transcription at
the IgM and the resulting isotype (IgG… by covering the target pathogen with the antibody. This …