… Many non-TP53 mutations have been documented in oral premalignant conditions, oral
dysplasia, and oral squamous cell carcinoma. Potentially, these mutations could contribute to …

… Immunohistochemical analysis Paraffin-embedded tissue sections were subjected to
immunohistochemical staining for p16 and p53 … and parabasal epithelial stratum of oral epithelial …

… precancerous lesions. We postulate that mutations identified in vulvar precancerous lesions
are present in oral precancerous … tract 13 , 25 ), p16 IHC staining and HPV RNA ISH were …

… 76 patients (68.46%) showed positive expression of the P53 gene. The degree of staining
of oral precancerous lesions for P53 is shown in Table 3. The expression level of the P53 …

… Abnormal p16 expression in squamous intraepithelial lesions … malignant tumours, present
in just over half of all human cancers. The detection of TP53 mutations in premalignant lesions …

… [ 7 ] P16 immunohistochemistry has been widely used for the detection of HPV in carcinoma
… expression of P16 in immunohistochemistry in premalignant and malignant oral lesions.[ 9 …

… p16-negative) with adjacent skin, and (2) to correlate the p53 … in VSCC and the associated
premalignant lesion. Finally, our … TP53 mutational profiles in VSCC and intraepithelial lesions …

… intraepithelial lesions or usual vulvar intraepithelial neoplasia [HSIL/uVIN]). IHC for p16 and
p53, and sequencing of TP53 … in premalignant and malignant epithelial lesions of the vulva. …

… mosaic pattern in the follicular infundibular hyperplasia (black lines) in this small follicular
cSCC with a null p16 in the tumour epithelium. (J) Same case showing the abrupt cut-off of null …

… protein in the tissue samples of oral cancerous and precancerous lesions.In the present …
study, tissue p53 immunoreactivity was assessed in OSCC and epithelial precursor lesions with …