HER2 Expression Is Predictive of Survival in Cetuximab Treated Patients with RAS Wild Type Metastatic Colorectal Cancer

SA Khelwatty, S Puvanenthiran, S Essapen, I Bagwan… - Cancers, 2021 - mdpi.com
… Similarly, other studies reported that EGFR expression was lost in 33% of metastasising …
Kaplan–Meier survival curves showing the impact on the OS of the patients with localised …

[HTML][HTML] Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives

E Martinelli, D Ciardiello, G Martini, T Troiani… - … of Oncology, 2020 - Elsevier
… 5-fluorouracil with a median overall survival (mOS) ranging from 8 to 12 … driver mutations that
affect the EGFR pathway. The … We evaluated the expression of EPHA2 by immunochemistry …

[HTML][HTML] AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer

C Cardone, B Blauensteiner, V Moreno-Viedma… - … Journal of Cancer, 2020 - Elsevier
… The potential prognostic effect of AXL expression in tumour stroma was also investigated. In
… AXL expression in tumour cells is a biomarker of poor survival in RAS WT mCRC patients. …

Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation

MM Atef, AI Amer, YM Hafez, MA Elsebaey… - British Journal of …, 2021 - Taylor & Francis
EGFR-AS1 in colorectal cancer is still unclear. We aimed to evaluate its expression in different
stages of colorectal cancer … Several studies have delineated the impact of EGFR-AS1 and …

EGFR-Based targeted therapy for colorectal cancer—Promises and challenges

B Janani, M Vijayakumar, K Priya, JH Kim… - Vaccines, 2022 - mdpi.com
… the survival of cancer cells, EGFR is a valuable target in the … to EGFR expression levels,
ligand binding to EGFR is … cytotoxicity effect against EGFR-overexpressing colon cancer cells (…

c-MYC expression is a possible keystone in the colorectal cancer resistance to EGFR inhibitors

A Strippoli, A Cocomazzi, M Basso, T Cenci, R Ricci… - Cancers, 2020 - mdpi.com
… time (PFS) and overall survival (OS), we found that patients with HME had a significant … the
effect of miR-31-3p, miR-143 and miR-145 on the c-MYC expression in colorectal cancer, we …

[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer

M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
… in colorectal cancer (CRC). The impact of KRAS mutations on the prognosis and survival
of … Interestingly, EGFR expression is found not to be correlated with the tumor response [82]. …

Epigenetically regulated gene expression profiles reveal four molecular subtypes with prognostic and therapeutic implications in colorectal cancer

X Wang, J Liu, D Wang, M Feng… - Briefings in …, 2021 - academic.oup.com
survival analysis and found patients who received ACT tended to show longer OS than … -III
patients with high frequencies of EGFR and BRAF mutations tended to benefit from only EGFR

Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis

CQ Wang, BF Huang, Y Wang, CH Tang, HC Jin… - Scientific reports, 2020 - nature.com
expression activate many downstream genes or pathways, such as epidermal growth factor
receptor (EGFR… nuclear HMGB1 and EGFR positive or β-catenin positive expression in CRC …

Survival improvement for patients with metastatic colorectal cancer over twenty years

FA Zeineddine, MA Zeineddine, A Yousef, Y Gu… - … Precision Oncology, 2023 - nature.com
… that Ras mutant tumors do not respond to anti-EGFR antibodies 55 and are … impact of
hepatic resection on survival, the length of survival is known to impact the possibility that patients