HER2 Expression Is Predictive of Survival in Cetuximab Treated Patients with RAS Wild Type Metastatic Colorectal Cancer
SA Khelwatty, S Puvanenthiran, S Essapen, I Bagwan… - Cancers, 2021 - mdpi.com
… Similarly, other studies reported that EGFR expression was lost in 33% of metastasising …
Kaplan–Meier survival curves showing the impact on the OS of the patients with localised …
Kaplan–Meier survival curves showing the impact on the OS of the patients with localised …
[HTML][HTML] Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives
E Martinelli, D Ciardiello, G Martini, T Troiani… - … of Oncology, 2020 - Elsevier
… 5-fluorouracil with a median overall survival (mOS) ranging from 8 to 12 … driver mutations that
affect the EGFR pathway. The … We evaluated the expression of EPHA2 by immunochemistry …
affect the EGFR pathway. The … We evaluated the expression of EPHA2 by immunochemistry …
[HTML][HTML] AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer
C Cardone, B Blauensteiner, V Moreno-Viedma… - … Journal of Cancer, 2020 - Elsevier
… The potential prognostic effect of AXL expression in tumour stroma was also investigated. In
… AXL expression in tumour cells is a biomarker of poor survival in RAS WT mCRC patients. …
… AXL expression in tumour cells is a biomarker of poor survival in RAS WT mCRC patients. …
Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation
… EGFR-AS1 in colorectal cancer is still unclear. We aimed to evaluate its expression in different
stages of colorectal cancer … Several studies have delineated the impact of EGFR-AS1 and …
stages of colorectal cancer … Several studies have delineated the impact of EGFR-AS1 and …
EGFR-Based targeted therapy for colorectal cancer—Promises and challenges
B Janani, M Vijayakumar, K Priya, JH Kim… - Vaccines, 2022 - mdpi.com
… the survival of cancer cells, EGFR is a valuable target in the … to EGFR expression levels,
ligand binding to EGFR is … cytotoxicity effect against EGFR-overexpressing colon cancer cells (…
ligand binding to EGFR is … cytotoxicity effect against EGFR-overexpressing colon cancer cells (…
c-MYC expression is a possible keystone in the colorectal cancer resistance to EGFR inhibitors
… time (PFS) and overall survival (OS), we found that patients with HME had a significant … the
effect of miR-31-3p, miR-143 and miR-145 on the c-MYC expression in colorectal cancer, we …
effect of miR-31-3p, miR-143 and miR-145 on the c-MYC expression in colorectal cancer, we …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
… in colorectal cancer (CRC). The impact of KRAS mutations on the prognosis and survival
of … Interestingly, EGFR expression is found not to be correlated with the tumor response [82]. …
of … Interestingly, EGFR expression is found not to be correlated with the tumor response [82]. …
Epigenetically regulated gene expression profiles reveal four molecular subtypes with prognostic and therapeutic implications in colorectal cancer
X Wang, J Liu, D Wang, M Feng… - Briefings in …, 2021 - academic.oup.com
… survival analysis and found patients who received ACT tended to show longer OS than … -III
patients with high frequencies of EGFR and BRAF mutations tended to benefit from only EGFR …
patients with high frequencies of EGFR and BRAF mutations tended to benefit from only EGFR …
Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis
… expression activate many downstream genes or pathways, such as epidermal growth factor
receptor (EGFR… nuclear HMGB1 and EGFR positive or β-catenin positive expression in CRC …
receptor (EGFR… nuclear HMGB1 and EGFR positive or β-catenin positive expression in CRC …
Survival improvement for patients with metastatic colorectal cancer over twenty years
… that Ras mutant tumors do not respond to anti-EGFR antibodies 55 and are … impact of
hepatic resection on survival, the length of survival is known to impact the possibility that patients …
hepatic resection on survival, the length of survival is known to impact the possibility that patients …