Are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance?

AJ Genders, GP Holloway, DJ Bishop - International Journal of Molecular …, 2020 - mdpi.com
… role of altered substrate oxidation by the mitochondria as a … insulin action is impaired, eg,
with insulin-resistant participants. … 31 P MRS, was decreased in insulin-resistant offspring [97], …

Mitochondrial dysfunction, insulin resistance, and potential genetic implications: potential role of alterations in mitochondrial function in the pathogenesis of insulin …

P Sangwung, KF Petersen, GI Shulman… - …, 2020 - academic.oup.com
… in muscle biopsy samples obtained from the insulin resistant … function in healthy, young,
lean, insulin resistant offspring of … deficiency leads to impaired mitochondrial function and …

Dissociation of muscle insulin resistance from alterations in mitochondrial substrate preference

JD Song, TC Alves, DE Befroy, RJ Perry, GF Mason… - Cell metabolism, 2020 - cell.com
… HFD)-fed insulin-resistant rats did not manifest altered muscle … in muscle mitochondrial
substrate oxidation explain muscle … the impairments in insulin-stimulated glucose oxidation we …

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

SM Frangos, DJ Bishop, GP Holloway - Biochemical Journal, 2021 - portlandpress.com
… enzymes involved in substrate oxidation. In support of this … impair mitochondrial bioenergetics
or induce skeletal muscle … present in obese/insulin resistant skeletal muscle also has the …

Altered mitochondrial metabolism in the insulinresistant heart

M Makrecka‐Kuka, E Liepinsh, AJ Murray… - Acta …, 2020 - Wiley Online Library
oxidative stress, impaired cytosolic and mitochondrial … ).146, 147 In the oxidative muscle
cells the diffusion of adenine … alter metabolic substrate oxidation in the cardiac mitochondria of …

Mitochondrial utilization of competing fuels is altered in insulin resistant skeletal muscle of non-obese rats (Goto-Kakizaki)

N Lai, CE Fealy, CM Kummitha, S Cabras… - Frontiers in …, 2020 - frontiersin.org
… in insulin-resistant skeletal muscle results in impaired … white fiber types in control and
insulin-resistant skeletal muscle. … contribution of substrate oxidation to the mitochondrial

Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers

M Bucher, KRC Montaniel, L Myatt… - … origins of health and …, 2021 - cambridge.org
… and insulin resistant from … impaired mitochondrial function.Petersen et al. have shown that
insulin resistance in the skeletal muscle of healthy, young, lean but insulin-resistant offspring

… diet aggravates fructose-induced mitochondrial damage in skeletal muscles and causes differentiated adaptive responses on lipid metabolism in adult male offspring

J Woyames, AFP Souza, RA Miranda… - The Journal of nutritional …, 2022 - Elsevier
substrate by this tissue in many metabolic conditions [8]. In fact, high-fructose ingestion
can impair muscles … ultrastructure of skeletal muscle of male adult offspring in a fiber type-specific …

A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring

C Hu, Y Yang, M Chen, X Hao, S Wang, L Yang… - European Journal of …, 2021 - Springer
muscle fiber types and mitochondrial function in offspring is … tolerance and muscle fiber
types in neonatal offspring and … to impair the glucose tolerance in the neonatal offspring, with …

Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice

H Lee, TY Ha, CH Jung, FS Nirmala… - … and Muscle, 2021 - Wiley Online Library
… IR is an important risk factor for type 2 diabetes, coronary heart … studies of obese and
insulin-resistant individuals who had … In this study, we show that impaired mitochondrial function …