… optimizing yield, stability and protein glycosylation through genetic engineering and the
manipulation of baculovirus vector and host cells. In this review, we summarize the strategies …

… L production volumes in single-use bioreactors, handling the … Similarly, in the production
of the metabolic by-product … as the cells continue to grow and no increase in cell diameter is …

… of how best to manipulate this platform. There is room for improvement in both the upstream
(… pathways, and noted that the cells enter a state of lower energy metabolism with the onset …

… cell lines with improved specific productivity. However, genetic engineering tools available
for manipulation … , culture age, culture state and energy metabolism, as well as the depletion …

… metabolism and its underlying transcriptional regulation are rewired during DNA virus/baculovirus …
The increase in amino acid metabolism caused by virus infection has been identified …

… to assuming that a cell’s metabolic activity remains same throughout the culture, … cell density
can also be manipulated using the proposed framework for process optimization at a higher …

… is employed to manipulate the glutamine-glutamate metabolic pathway. Comparative …
In this project, strategies to enhance recombinant protein production in the baculovirus-Sf9 …

… than mammalian cells, they can easily be manipulated using a … Sf-9 cells showed better
rate of amplification of baculovirus … the carbohydrate metabolism in the insect cells. Sf-9 and …

… their ease of genetic manipulation, simple production and their … a cellular metabolism
biosensor, AMPFret. This biosensor was first optimised to enhance the cellular sensitivity through …

… on the production of baculoviruses in vitro using insect cell … metabolism of Sf9 cells is
progressively inhibited when cell … aiming to improve in vitro production of baculoviruses it is useful …