Current perspectives in human T-cell leukemia virus type 1 infection and its associated diseases

M Miura, T Naito, M Saito - Frontiers in Medicine, 2022 - frontiersin.org
… Although most HTLV-1-infected individuals remain asymptomaticcells (PBMCs)]; PVL varies
by 1,000-fold among ACs (26, 27). It … the proliferation of HTLV-1-infected T cells in vitro (92). …

Human T-cell lymphotropic virus type-1: a lifelong persistent infection, yet never truly silent

A Hirons, G Khoury, DFJ Purcell - The Lancet Infectious Diseases, 2021 - thelancet.com
… mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T
cells. … Striking a balance between proliferation and survival of cells infected with HTLV-…

Mother-to-child transmission of human T-cell leukemia virus type 1: mechanisms and nutritional strategies for prevention

K Itabashi, T Miyazawa - Cancers, 2021 - mdpi.com
… of HTLV-1-infected individuals remain asymptomatic, it is … between DCs and T cells, as
well as between T cells [46,57]. … to the basal surface of an epithelial cell (transcytosis) [74]; (2) …

Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines

CA Pise-Masison, G Franchini - Viruses, 2022 - mdpi.com
… of HTLV-1-infected individuals remain asymptomatic, after a … between the virus-infected CD4
+ T-cell and uninfected cells. The … CD8 + T-cells, also called cytotoxic T lymphocytes (CTLs). …

Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
… transformation of HTLV-1-infected T cells. Moreover, several … -1 is abundant in resting,
non-proliferating CD4+ T cells and … of HTLV-1-infected individuals, asymptomatic carriers, and ATL …

Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival

R Hleihel, H Skayneh, H de Thé, O Hermine… - Blood Cancer …, 2023 - nature.com
… with human T cell leukemia virus type 1 (HTLV-1). The … , paramount for the proliferation and
survival of infected T cells [5, 9]. … -1 [43], is constantly expressed in asymptomatic carriers or …

HTLV-1 replication and adult T cell leukemia development

CZ Giam - Viruses and Human Cancer: From Basic Science to …, 2021 - Springer
Human T-cell leukemia virus type 1 (HTLV-1) was … While HTLV-1 infection is generally
asymptomatic, 35% of … an intractable leukemia/lymphoma of CD4+ T cells known as adult T cell

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
T lymphocytes caused by human T lymphotropic virus type-1 (… HTLV-1 infection is
asymptomatic in the majority of subjects; … mechanisms during interactions between virus and host …

Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF

…, V Castro, A Chen-Liaw, Z Skidmore, T Ueno… - PLoS …, 2021 - journals.plos.org
… , or remain as asymptomatic carriers (AC) [3]. Despite … -1 host carries between 10 4 and
10 5 infected T-cell clones, … genes in normal CD4+ T lymphocytes, with the shaded gene …

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

WH Khoo, K Jackson, C Phetsouphanh, JJ Zaunders… - Clinical …, 2023 - Elsevier
… SARS-CoV-2 leaves a small footprint in the circulating T cell … to higher basal expression of
the MDA5 and RIG-1 viral pattern … t-test to compare between 2 groups and paired Student's t-…