… immunomodulatory drugs (IMiD; Thalidomide, Lenalidomide … For example, combination of
rapamycin with perifosine, an … single agent despite having promising anti-myeloma capabilities…

… immunomodulatory drugs (IMiDs) such as lenalidomide or … inhibiting activity displayed
promising anti-myeloma activity [80]. … perifosine combined with BTZ revealed increase cytotoxicity …

… paired with existing and novel agents to induce high clinical … Bortezomib with lenalidomide
and dexamethasone versus … promote resistance to antimyeloma drugs through upregulation …

… dependent cytotoxicity in Doxorubicinresistant, Lenalidomide… -vitro study showed that although
significant anti-myeloma effects … with perifosine against Akt. J Hematol Oncol. 2013;6:18. …

… drugs such as proteasome inhibitors (eg, bortezomib and carfizomib), immunomodulatory
drugs (eg, thalidomide and lenalidomide)… as a potent anti-myeloma agent in vitro and in animal …

… , and it enhances the anti-myeloma activity of bortezomib [34,… with other chemotherapeutic
drugs (dexamethasone; lenalidomide; … with carfilzomib, bortezomib and/or lenalidomide, and …

… anti-myeloma agents. It is still early to assess whether these … evaluated the combination of
perifosine with bortezomib and … and 27% discontinued lenalidomide due to toxicity which was …

… or SD improved response in both bortezomib-relapsed and refractory patients … In this study
of 445 patients, lenalidomide plus low-dose … In addition to demonstrated anti-myeloma activity, …

… Akt inhibitor perifosine induces significant cytotoxicity in MM … - or proteasome inhibitor
bortezomib-induced cytotoxicity [30]. … -tolerated dose of perifosine-lenalidomide-dexamethasone …

… , novel therapeutic targets and drugs are … drugs have been reported to act through an ER
stress response in different human cancers, including bortezomib (also known as Velcade or PS…