… and its impact within in vitro setups for inhaled drugs and formulations: Identifying the limits of simple vs. complex methodologies when studying drug dissolution and …
S Radivojev, L Kargl, JT Pinto, M Swedrowska… - International Journal of …, 2024 - Elsevier
… , dissolution and absorption), which … study was focused on the question how added mucus
and its composition can reflect the impact on the drug dissolution and drug permeation in vivo. …
and its composition can reflect the impact on the drug dissolution and drug permeation in vivo. …
Development of an in vitro system to study the interactions of aerosolized drugs with pulmonary mucus
… ciclesonide as part of a drug dissolution study [26]. This was then … airway mucus could
interfere with the absorption of inhaled bronchodilators in the lungs. The impact of mucus on drug …
interfere with the absorption of inhaled bronchodilators in the lungs. The impact of mucus on drug …
Size effect of curcumin nanocrystals on dissolution, airway mucosa penetration, lung tissue distribution and absorption by pulmonary delivery
… influences the drug release and absorption process of NCs. In this … In conclusion, this study
demonstrated that smaller sized … It has been reported that the airway mucus had a mesh …
demonstrated that smaller sized … It has been reported that the airway mucus had a mesh …
Dissolution and absorption of inhaled drug particles in the lungs
… vitro dissolution testing methods developed for dry powder particles, and models commonly
used to study absorption of inhaled drug. … The system consists of a mucus layer (50 μm thick …
used to study absorption of inhaled drug. … The system consists of a mucus layer (50 μm thick …
Simulation of respiratory tract lining fluid for in vitro dissolution study
… airways and alveoli, so that they are absorbed and have therapeutic action. Artificial simulated
RTLFs are often used for in vitro dissolution … the framework of the airways mucus gel and …
RTLFs are often used for in vitro dissolution … the framework of the airways mucus gel and …
Development of in vitro evaluation system for assessing drug dissolution considering physiological environment in nasal cavity
D Inoue, A Yamashita, H To - Pharmaceutics, 2022 - mdpi.com
… effective for the improvement of drug absorption from powders. This … study, we developed
an in vitro system to evaluate the drug dissolution of powder formulations into nasal mucus…
an in vitro system to evaluate the drug dissolution of powder formulations into nasal mucus…
[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …
P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
… ; the DissolvIt with a mucous gel simulant and data for two … to cross-validate the dissolution-
and absorption kinetics of two … dissolution- and absorption kinetics of the study solutes in …
and absorption kinetics of two … dissolution- and absorption kinetics of the study solutes in …
To enhance mucus penetration and lung absorption of drug by inhalable nanocrystals-in-microparticles
G Huang, S Shuai, W Zhou, Y Chen, B Shen, P Yue - Pharmaceutics, 2022 - mdpi.com
… -NS with mucus in order to evaluate the mucin adsorption and mucus-… -drying, and to
investigate the redispersibility, dissolution and … (4) To study the drug retention in lung and the in …
investigate the redispersibility, dissolution and … (4) To study the drug retention in lung and the in …
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties
BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
… neutral range for airway mucus [29]. … effect in the gastrointestinal mucosa, the pH-dependent
repulsion between mucins can have detrimental effects on the viscosity and thus the mucus …
repulsion between mucins can have detrimental effects on the viscosity and thus the mucus …
The effect of ingredients commonly used in nasal and inhaled solutions on the secretion of mucus in vitro
MMRR Ayoub, MI Lethem, AB Lansley - International Journal of …, 2021 - Elsevier
… and the mucus could provide a barrier to drug absorption. … *FF is practically insoluble in
water and was dissolved in … as a marker of ovine airway mucous secretion. Due to species …
water and was dissolved in … as a marker of ovine airway mucous secretion. Due to species …