Electrospun-fibrous-architecture-mediated non-viral gene therapy drug delivery in regenerative medicine

E Cojocaru, J Ghitman, R Stan - Polymers, 2022 - mdpi.com
… of non-viral vectors is the protection of carried gene therapy … of viral and non-viral vectors
in gene therapy drug delivery are … mimicking nanofiber scaffolds with their controlled delivery

Controlled pVEGF delivery via a gene-activated matrix comprised of a peptide-modified non-viral vector and a nanofibrous scaffold for skin wound healing

S He, J Fang, C Zhong, F Ren, M Wang - Acta Biomaterialia, 2022 - Elsevier
… formation by combining gene delivery with functional scaffolds to create gene-activated …
long-term gene delivery properties remains a challenge. In this study, a non-viral DNA delivery

Application of electrospun materials in gene delivery

GSNK Rao, M Kurakula… - Electrospun Materials and …, 2020 - Wiley Online Library
… Electrospun nanofibrous scaffolds area is the leading research field in gene therapy with
their … In this chapter, detailed information about gene therapy, comparison of viral with non-viral

Scaffold-based non-viral CRISPR delivery platform for efficient and prolonged gene activation to accelerate tissue regeneration

C Zhong, S He, Y Huang, J Yan, J Wang, W Liu, J Fang… - Acta Biomaterialia, 2024 - Elsevier
… developed a CRISPRa non-viral gene delivery platform by immobilizing non-viral CRISPRa
complexes into a biocompatible hydrogel/nanofiber (Gel/NF) composite scaffold. The Gel/NF …

Advanced gene nanocarriers/scaffolds in nonviral-mediated delivery system for tissue regeneration and repair

W Zhang, Y Hou, S Yin, Q Miao, K Lee, X Zhou… - Journal of …, 2024 - Springer
… This paper reviews the recent advances on nonviral-mediated gene delivery systems with
an emphasis on the important role of advanced nanocarriers in gene therapy and tissue …

Genetically Engineered Viral Vectors and Organic‐Based NonViral Nanocarriers for Drug Delivery Applications

S Hajebi, S Yousefiasl, I Rahimmanesh… - Advanced …, 2022 - Wiley Online Library
… Natural polymers have received much attention in many medical fields as wound dressings,
adsorbents, drug delivery, and medical scaffolds due to properties such as metabolic …

A summary on non-viral systems for gene delivery based on natural and synthetic polymers

R Sarvari, M Nouri, S Agbolaghi… - … Journal of Polymeric …, 2022 - Taylor & Francis
… for the non-viral vectors to … non-viral gene delivery because of their facile synthesis and
flexible characteristics [ Citation 51 ] . The polymers are capable of being intimate with the genetic

Scaffold-mediated non-viral delivery of nucleic acids for sustained gene silencing in regenerative medicine

JS Chin - 2022 - dr.ntu.edu.sg
… Beyond non-viral delivery of nucleic acids, CRISPR/Cas9 components were also delivered
in a localized and non-viral manner via electrospun scaffolds. Specifically, using mussel-…

Designing electrospun fiber platforms for efficient delivery of genetic material and genome editing tools

DL Puhl, D Mohanraj, DW Nelson, RJ Gilbert - Advanced drug delivery …, 2022 - Elsevier
… editing tools via viral and non-viral vectors are approaches to control … low delivery efficiencies
slow the progression of gene delivery strategies to clinical settings. The delivery of genetic

Scaffolds for drug delivery and tissue engineering: The role of genetics

A Zielińska, J Karczewski, P Eder… - … Clinics and Research, 2023 - journals.lww.com
… Naked plasmids and non-viral vectors initiate milder … The plasmid can transfect cells in
vivo but has low in vitro efficiency. … The use of nanofiber scaffolds to develop 3D nanofiber