… For human PKPD we focus on early bactericidal activity studies and … models are useful in
the tuberculosis drug development space with the ability to inform future clinical trial design by …

… principles of translational anti-infective pharmacology, … resistant forms of TB with significant
emphasis on treatment … , such as the hollow-fiber model for TB and CHIM for malaria, are …

… New anti-TB drug discovery, is now more than ever, focused on finding new anti-… in anti-TB
drug discovery and development, relative to both old therapeutic agents and drugs with …

… Another study also applied a linear regression approach, but focused on the prediction of
the AUC 0–24 h of rifampicin and other TB drugs during the first 3 days of treatment [34]. In the …

… focus on computational methods spanning empirical, pharmacokinetic-pharmacodynamic
(… and ongoing challenges in TB drug development that PK-PD modeling can improve, …

… The anti-infective PK/PD models predict the relationship … ) model and a model of tuberculosis
infection in mice. The … studies with PK/PD modeling focused on antibacterials compared to …

… of the pharmacokinetic-pharmacodynamic relationship. The … other anti-infective agents (3,
4). Coadministration of multiple … in this study, we only focused on the blood partitioning of the …

… treatment stratification is currently focused on baseline measurements. … These models enable
prediction of early drug effect, but … translation to drug development and clinical programs. …

… If a new anti-infective has potential against respiratory … the elucidation of
pharmacokinetic-pharmacodynamic relationships … This infection is caused by Mycobacterium …

… and pharmacokinetic/pharmacodynamic (PK/PD) in vitro … response in situ and to reveal
anti-infective effects. Conversely, the main … from the knowledge and models developed for TB, the …