… structures is sensitive to the speed of transcription and may … splicing to transcript elongation
and other cotranscriptional … At the commitment step, bridging occurs between U1 snRNP at …

… approximately 50% of velocity-sensitive genes 31 . In the latter … While our co-transcriptional
splicing commitment models … mode of co-transcriptional binding slower transcript elongation …

… transcription elongation and its effect on alternative splicing. … the rapid and co-transcriptional
selection of splice sites and … the kinetics of splicing catalysis during transcription in yeast, a …

… that the 3′ETS stem-loop is a Pac1 target in vivo and in vitro (20,21). Because of this association,
… 02Δ mutant showed increased H 2 O 2 sensitivity compared to wild-type fission yeast (…

… analysis in a temperature-sensitive mutant of yeast. Fission … independently in an in vitro
transcription system (Dengl and … that exhibits slow elongation rate phenotype in yeast, rescued …

… Pre-mRNA splicing in vivo is intimately coupled with transcription both physically and
functionally. … How are short exons flanked by long introns defined and committed to splicing?. …

… a cold-sensitive growth phenotype and moderate splicing defects. … ′ splice site (5′ ss) and
forming the first commitment complex … in vitro, cell culture, or other metazoan model systems. …

… This folding is sensitive to the rate of transcript elongation, … of co-transcriptional RNA processing
in vivo have revealed the … have been established in a variety of systems, including yeast, …

… transcription elongation rate remain poorly understood. We show here that the conserved
fission yeast RNA-… For the cells where the seb1 gene was under the thiamine-sensitive nmt1 …

… in yeast and found that a component of transcriptional complex … enzyme catalyzing the first
committed step in GMP biosynthesis (… co-transcriptional splicing, we looked at the transcription …