Pre-mRNA splicing and its cotranscriptional connections
H Shenasa, DL Bentley - Trends in Genetics, 2023 - cell.com
… structures is sensitive to the speed of transcription and may … splicing to transcript elongation
and other cotranscriptional … At the commitment step, bridging occurs between U1 snRNP at …
and other cotranscriptional … At the commitment step, bridging occurs between U1 snRNP at …
[HTML][HTML] Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
T Horn, A Gosliga, C Li, M Enculescu… - npj Systems Biology and …, 2023 - nature.com
… approximately 50% of velocity-sensitive genes 31 . In the latter … While our co-transcriptional
splicing commitment models … mode of co-transcriptional binding slower transcript elongation …
splicing commitment models … mode of co-transcriptional binding slower transcript elongation …
Linking transcription, RNA polymerase II elongation and alternative splicing
LE Giono, AR Kornblihtt - Biochemical Journal, 2020 - portlandpress.com
… transcription elongation and its effect on alternative splicing. … the rapid and co-transcriptional
selection of splice sites and … the kinetics of splicing catalysis during transcription in yeast, a …
selection of splice sites and … the kinetics of splicing catalysis during transcription in yeast, a …
Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast
C Yague-Sanz, M Duval, M Larochelle… - Nucleic acids …, 2021 - academic.oup.com
… that the 3′ETS stem-loop is a Pac1 target in vivo and in vitro (20,21). Because of this association,
… 02Δ mutant showed increased H 2 O 2 sensitivity compared to wild-type fission yeast (…
… 02Δ mutant showed increased H 2 O 2 sensitivity compared to wild-type fission yeast (…
[图书][B] Termination-Independent Role of RAT1 in Cotranscriptional Splicing in Budding Yeast
ZH Dhoondia - 2020 - search.proquest.com
… analysis in a temperature-sensitive mutant of yeast. Fission … independently in an in vitro
transcription system (Dengl and … that exhibits slow elongation rate phenotype in yeast, rescued …
transcription system (Dengl and … that exhibits slow elongation rate phenotype in yeast, rescued …
[HTML][HTML] Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing
… Pre-mRNA splicing in vivo is intimately coupled with transcription both physically and
functionally. … How are short exons flanked by long introns defined and committed to splicing?. …
functionally. … How are short exons flanked by long introns defined and committed to splicing?. …
Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast
S Chalivendra, S Shi, X Li, Z Kuang, J Giovinazzo… - RNA, 2024 - rnajournal.cshlp.org
… a cold-sensitive growth phenotype and moderate splicing defects. … ′ splice site (5′ ss) and
forming the first commitment complex … in vitro, cell culture, or other metazoan model systems. …
forming the first commitment complex … in vitro, cell culture, or other metazoan model systems. …
Co-transcriptional gene regulation in eukaryotes and prokaryotes
M Shine, J Gordon, L Schärfen, D Zigackova… - … Reviews Molecular Cell …, 2024 - nature.com
… This folding is sensitive to the rate of transcript elongation, … of co-transcriptional RNA processing
in vivo have revealed the … have been established in a variety of systems, including yeast, …
in vivo have revealed the … have been established in a variety of systems, including yeast, …
[HTML][HTML] The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression
M Duval, C Yague-Sanz, TW Turowski… - Nature …, 2023 - nature.com
… transcription elongation rate remain poorly understood. We show here that the conserved
fission yeast RNA-… For the cells where the seb1 gene was under the thiamine-sensitive nmt1 …
fission yeast RNA-… For the cells where the seb1 gene was under the thiamine-sensitive nmt1 …
Prp5− Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription
W Shao, Z Ding, ZZ Zheng, JJ Shen… - Nucleic acids …, 2020 - academic.oup.com
… in yeast and found that a component of transcriptional complex … enzyme catalyzing the first
committed step in GMP biosynthesis (… co-transcriptional splicing, we looked at the transcription …
committed step in GMP biosynthesis (… co-transcriptional splicing, we looked at the transcription …