… Forward genetic screens in animal models have helped elucidate causal links. … genetic
approaches in common animal model species: two invertebrates, nematodes (Caenorhabditis …

… We utilized genome sequencing to identify a novel LQTS genetic substrate in a … Therefore,
ALG10B is a novel LQTS-susceptibility gene underlying the LQTS phenotype observed in a …

… a correlation analysis to identify assays with activity patterns similar … the activities of the
anti-SARS-CoV-2 compounds identified … in vitro assays against new targets typically identify many …

… vitro human ether-a-go-go-related gene (hERG) assay is one component of an integrated risk
assessment for delayed ventricular repolarization. Function … change of KCNH2 expression …

… in vitro screening, if a compound shows the potential to inhibit hERG (human ether-a-go-go
related gene… investigating how xenobiotics/toxicants affect gene expression (transcriptomics), …

… Environmental factors such as temperature affect neuronal activity and development. … how
they affect synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans …

… a contribution of endogenously modified SOD1 to protein … The in vivo rat plasma half-life was
3.6 h, with an oral … no effect on the human ether-a-go-go related gene (hERG) channel or on …

… of the ability of NPs to affect gene expression in cells. An in vitro study showed that cationic
… While in vitro human ether-a-go-go-related gene (hERG) testing, safety pharmacology for non…

… Next, we performed a two-stage in vivo functional assay. We … Drugs known to affect the
proteins of interest in the desired … ] was used for Caenorhabditis elegans ortholog assignation. …

… Caenorhabditis elegans is highly suited to study the effects of … be easily achieved in other
in vivo models. Certainly, there … We observed no change in the amplitude of ΔF/F 0 for CPVT-…