… (18F-AV-45 or flobetapir F 18). Methods: An open-label, multicenter brain imaging, metabolism,
and safety study of 18F-AV-45 … 18F-AV-45 accumulated in cortical regions expected to be …

… Alzheimer's disease in patients with dementia. Also, they are frequently used in selecting
patients participating drug trials aiming to reduce β-amyloid (… of β-amyloid deposits. Distribution …

… These tracers showed high initial uptake in the brain and washed out rapidly due to
absence of β-amyloid deposits in a normal mouse brain. In Alzheimer’s patients, [ 18 F]AV-45 …

… by the inhibition binding test using [ 18 F]AV45 as a competitive radioligand. From Table 1,
it … mechanism to explain the difference in in vivo imaging ability. Subsequently, reliable MS …

… Imaging characteristic of dual-phase (18)F-florbetapir (AV-45/Amyvid) PET for the … amyloid
deposition in Alzheimer's disease and mild cognitive impairment. Eur J Nucl Med Mol Imaging …

… diagnosis time of AD, in vivo imaging of Aβ plaques in the … A AD transgenic mice; B WT mice;
C radioligand binding was … DRKXH1 retention in recognized amyloid deposit areas, such as …

… The main pathological features of AD are intracerebral amyloid deposition and NFT in the
brain. The current clinical diagnosis of AD is mainly based on clinical history and excludes …

… The increased white matter distribution decreases the differences between specific and
non-specific binding, where specific binding is defined as radioligand binding to amyloid while …

… the expected uptake patterns of these radioligands and their diagnostic implications. … further
support that amyloid deposition predates cognitive decline, and PET imaging may provide a …

… neurofibrillary tangles, hallmarks of Alzheimer disease (AD), … the localization of amyloid
deposition changes overtime within … as antibody-based radioligands for even greater specificity …