Induction of antigen-specific tolerance in T cell mediated diseases

L Passerini, S Gregori - Frontiers in Immunology, 2020 - frontiersin.org
… tolerogenic arm of the immune system would restore the immune homeostasis and control
the … by tolDC are promising tools for the reprogramming of pathogenic T cells and induction of …

Tissue‐Targeted Drug Delivery Strategies to Promote AntigenSpecific Immune Tolerance

Y Rui, HB Eppler, AA Yanes… - Advanced healthcare …, 2023 - Wiley Online Library
… for high concentrations of immune cells to encounter each other… for immune reprogramming
could promote antigen-specific … key immune cell subsets involved in the induction of immune

Inducing immune tolerance with dendritic cell-targeting nanomedicines

A Cifuentes-Rius, A Desai, D Yuen… - Nature …, 2021 - nature.com
… leverages the cells and function of the immune system to quell … of isolating and reprogramming
dendritic cells (DCs), central … antigen-specific immune tolerance is achieved by inducing T …

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance

YD Muller, LMR Ferreira, E Ronin, P Ho… - Frontiers in …, 2021 - frontiersin.org
cells or by the recipient mice. Altogether, we demonstrate that genome-engineered mono-antigen-specific
A2-… and exhibit antigen-dependent in vivo suppression, independent of TCR …

[PDF][PDF] Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective

S Sakaguchi, R Kawakami… - Immunotherapy …, 2023 - academic.oup.com
… strategies for Treg-based immune suppression and the issues to be resolved for achieving
stable antigen-specific immune suppression and tolerance … The recipient immune system

[HTML][HTML] Immune tolerance induced by immune-homeostatic particles

G Chen, H Zhang, H Wang, F Wang - Engineered Regeneration, 2021 - Elsevier
Immune tolerance, a status of immune system unreacted to … and successive precise T cell
programming process. Extensive … and autoantigens to induce antigen-specific Tregs have been …

Nanoparticle platforms for antigen-specific immune tolerance

EB Thorp, C Boada, C Jarbath, X Luo - Frontiers in immunology, 2020 - frontiersin.org
… nanoparticles to antigen-specific immune cell subsets (84). This effectively mimics the function
of the … Additional strategies for reprograming antigen-exposed dendritic cells for immune

Cell fate reprogramming in the era of cancer immunotherapy

O Zimmermannova, I Caiado, AG Ferreira… - Frontiers in …, 2021 - frontiersin.org
technologies for generation of immune cells by cell fate … As their natural role lies in the
maintenance of self-tolerance, … ability to activate antigen-specific cytotoxic T-cells via antigen cross-…

Restoring tumor immunogenicity with dendritic cell reprogramming

O Zimmermannova, AG Ferreira, E Ascic… - Science …, 2023 - science.org
cells to evade the immune system. We used the minimal gene regulatory network of type
1 conventional dendritic cells (cDC1) to reprogram cancer cells … in vitro tumor antigenspecific

Lymph node-targeted synthetically glycosylated antigen leads to antigen-specific immunological tolerance

CD Maulloo, S Cao, EA Watkins, MM Raczy… - Frontiers in …, 2021 - frontiersin.org
induce antigen-specific immunological tolerance, and investigate the molecular mechanisms
of tolerance. … as downstream effects on the antigen-specific T cell response. We furthermore …