… in OX-161 cells and prevented cyst growth in ex vivo and 3D … retarded cyst development and
mitigated renal function decline. … to evaluate renal function in PKD mice following treatment. …

… the renal cystogenesis caused by loss of Ift88 is prevented … of autosomal dominant polycystic
kidney disease, indicating that … effects of Itgb1 inactivation on fibrosis in Ift88 KO kidneys, we …

… of cystic kidney diseases including polycystic kidney disease (… In addition, Integrin β1 both
associates [30] and is cleaved by … Inactivation of ILK in collecting ducts of PKHD1 or pcy mice …

Polycystic kidney disease (PKD) is characterized by extensive cyst formation and progressive
fibrosis. However, the molecular mechanisms whereby the loss/loss-of-function of …

… WT-1 immunohistochemistry was performed on mouse renal tissue sections to estimate
podocyte loss. In both cases, sections were fixed in ice-cold acetone for 1 minute after antigen …

… complex, since the other end of the complex is anchored to latent transforming growth factor
β binding protein (LTBP) cross-linked to the extracellular matrix [26]. Following release from …

… polycystic kidney disease (ADPKD) is a prevalent hereditary disorder primarily affecting the
kidneys. It is … a second mutation, leading to the deactivation of the remaining as normal allele. …

… autosomal dominant polycystic kidney disease providing a … , since mechanical tension can
block endocytosis and prevent … been shown that in zebrafish, inactivation of Pkd1 leads to an …

… We also found that Stat3 inactivation led to increased … for 18 weeks (12 weeks after the
completion of doxycycline treatment)… inactivation does not prevent cystic kidney growth nor kidney …

… , many patients still develop kidney failure and require costly … Further, knockdown of integrin
β1 prevented HG-induced … therapeutically since inhibition of csGRP78/integrin β1 interaction …