… Chronic kidney disease (CKD) is a worldwide public health … ECM degradation and CK
inactivation and to resistance to … adhesion site in the βA domain of the integrin β1 subunit [56,57]. …

… Following mutation accumulation, adenomas, which display … Loss of a functional TP53,
including inactivating mutations, … , we have shown that integrin β1 can promote proliferative …

… ADAMs-mediated shedding of growth factors causes cell growth or proliferation by
transactivation of the growth factor receptors including epidermal growth factor receptor. Therefore, …

… , their inactivation was found to be beneficial for preventing … -fibrotic HSCs and ablation of
integrin β1 in HSCs impedes the … to progressive kidney damage and chronic kidney disease (…

… Renal fibrosis (RF) is an essential intermediate link and the final pathological change during
the development of chronic kidney disease … following millions of years of evolution. They …

… kidney ECM plays a critical role in preventing cyst formation and phenotypes as seen in
nephronophthisis or polycystic kidney disease… the conditional inactivation of integrin β1 in mouse …

… -duct-specific deletion of Itgb1 (integrin β1) results in severe … kidney diseases, including
CAKUT. Madin-Darby canine … throughout the developing kidney with enrichments within later-…

… chronic kidney disease (CKD) and end-stage renal disease (… NF-κB signaling but inactivating
the fibrotic Smad3 signaling [80]. … Furthermore, DPP-4 also interacts with integrin β1 to …

… However, since TGFβ itself plays a dual role in … ILK localizes to integrin β1 and β3 to form
a scaffolding complex, … /TAZ co-activator inactivation and this inactivation inhibits its nuclear-…

… In the present study, since the number of attached RCC cells … Integrin β1 also plays an
important role in the development of … is also reflected by its deactivation of FAK. FAK serves as a …