Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short‐term disuse in healthy younger humans

CRG Willis, IJ Gallagher, DJ Wilkinson… - The FASEB …, 2021 - Wiley Online Library
lack of direct evidence for any quantifiable change in MPB in … least one of the predicted
transcription factors for that module (… Analysis of human skeletal muscle after 48 h immobilization …

Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults

AB Rubenstein, JM Hinkley, VD Nair… - American Journal …, 2022 - journals.physiology.org
… for this analysis due to insufficient tissue obtained from biopsy … that examined transcript
profiles in individual muscle fibers (… with human clinical and skeletal muscle phenotyping. PLIER …

Dietary protein considerations for muscle protein synthesis and muscle mass preservation in older adults

ET Olaniyan, F O'Halloran… - Nutrition Research …, 2021 - cambridge.org
Transcription factors like SRF (serum response factor) help regulate skeletal muscle growth(13)
Inadequate protein and energy consumption in older adults can contribute to decreased …

[HTML][HTML] Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults

AS Kulkarni, BD Peck, RG Walton, PA Kern… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… The purpose of this study was to profile the muscle … our primary outcomes paper is the
lack of a sedentary control … of the reference human genome, with transcript annotations (…

Reduced physical activity alters the leucine-stimulated translatome in aged skeletal muscle

ZS Mahmassani, AI McKenzie… - The Journals of …, 2021 - academic.oup.com
… , this analysis was not performed in skeletal muscle or in humans (18). Our laboratory has
… studies in older adults that also did not demonstrate many transcription changes using …

[HTML][HTML] Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans

S Joanisse, C Lim, J McKendry, JC Mcleod… - …, 2020 - ncbi.nlm.nih.gov
… as modification to histones, transcription factors, satellite cells, and… This low protein:RNA ratio
results in an incomplete … , express a pro-inflammatory gene profile at rest and respond to an …

Protein metabolism and related body function: mechanistic approaches and health consequences

D Tomé, S Benoit, D Azzout-Marniche - Proceedings of the Nutrition …, 2021 - cambridge.org
… -derepressible 2/activating transcription factor 4 system or the … and skeletal muscle fibre
decrease in older women fed a low-… skeletal muscle to protein intake in older subjects(142). The …

Dietary interventions and molecular mechanisms for healthy musculoskeletal aging

A Murphy, S Vyavahare, S Kumar, TJ Lee, A Sharma… - Biogerontology, 2022 - Springer
transcription profile upon skeletal muscle analysis, indicating a potential correlation between
low IGF… Moreover, gene expression profiling of CR human skeletal muscle found significant …

An integrated approach to skeletal muscle health in aging

D Agostini, M Gervasi, F Ferrini, A Bartolacci… - Nutrients, 2023 - mdpi.com
… the gut microbiota profile correlates with changes in muscle mass [90]… Muscle-specific activation
of the transcription factor NF-κB … A lack of vit D promotes skeletal muscle protein and lipid …

Do skeletal muscle composition and gene expression as well as acute exercise-induced serum adaptations in older adults depend on fitness status?

DA Bizjak, M Zügel, U Schumann, MA Tully… - BMC geriatrics, 2021 - Springer
… the combination of obesity and low muscle mass, is a serious … variability in the expression
profiles which may contribute to … beneficial adaptations in the transcription and transport of …