[HTML][HTML] Inflammasome in skeletal muscle: NLRP3 is an inflammatory cell stress component in inclusion body myositis

K Kummer, I Bertram, S Zechel, DB Hoffmann… - International Journal of …, 2023 - mdpi.com
… pro-inflammatory cell culture model using human myoblasts and primary human myotubes.
… We found a significant increase of the mRNA level for NLRP3 in stimulated cells compared …

[HTML][HTML] Inclusion body myositis and neoplasia: A narrative review

L Damian, CC Login, C Solomon, C Belizna… - International Journal of …, 2022 - mdpi.com
… inflammatory infiltrate, or increasing the expression of … aggregation in cell cultures and mouse
experimental myositis [4,… report all cancers in this aging population where the cancer risk is …

Investigating the influence of inflammatory mediators on non-inflammatory features of sporadic inclusion body myositis in vitro

B McCord - 2023 - discovery.ucl.ac.uk
… size of p62 puncta, but this may represent increased autophagic flux instead of … cultures
with sIBM-like inflammatory mediators may be warranted to investigate muscle weakness. …

[HTML][HTML] Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis

C Nelke, CB Schroeter, L Theissen, C Preusse… - Acta …, 2023 - Springer
… For primary human skeletal muscle cell (PHMC) purification, … These PHMC cultures contain
different degrees of myoblast … level by PCR observing an increased expression of CDKN1A (…

[HTML][HTML] Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

Y Oikawa, R Izumi, M Koide, Y Hagiwara, M Kanzaki… - PLoS …, 2020 - journals.plos.org
… Because our results raise the possibility of the … that the GDF15 level in myoblast culture
medium was increased by BSO and … found in cardiac and skeletal muscles during aging [52]. The …

Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis

KA Britson, JP Ling, KE Braunstein… - Science translational …, 2022 - science.org
Aging is known to diminish the regenerative capacity of … that muscle from subjects with IBM
exhibits increased numbers of … with in vitro studies showing primary myotubes cultured with …

Safety and tolerability of phenylbutyrate in inclusion body myositis

D Jabari, A Heim, A Ciersdorff, H Wilkins… - RRNMF …, 2024 - journals.ku.edu
… , associated with intracellular aging of muscle fibers, is thought to … Studies have suggested
that cultured human muscle fibers (… , in addition to significantly increased amyloid-beta and its …

[HTML][HTML] Serum-Circulating microRNAs in Sporadic Inclusion Body Myositis

M Lucchini, V De Arcangelis, M Santoro… - International Journal of …, 2023 - mdpi.com
… alterations (major histocompatibility … muscle differentiation and regeneration, and LATS2
and VEGFA for hsa-miR-372-3p, which are involved in skeletal muscle growth and aging. We …

There and Back Again: Developing a Xenograft Model of Sporadic Inclusion Body Myositis for Translational Research

KA Britson - 2020 - search.proquest.com
… to structures observed in cultured myxovirus-infected cells, it … showed increased levels of
βAPP and Aβ in skeletal muscle … mdx mutation caused a muscle intrinsic primary myopathy, it …

Inclusion body myositis: evolving concepts.

T Mozaffar, M Perez-Rosendahl - Current Opinion in Neurology, 2022 - escholarship.org
… in IBM muscle and controls, suggesting an accelerated aging … the primary driver of the
disease.(37) The development of IBM-specific pathology in myotube cultures and mouse muscles