… high expressed and activated in various cancers. Therefore, they can be considered as potential
… Overexpression of sPLA 2 -IIA (initially termed membrane-associated PLA 2 , M-PLA 2 ) …

… The term cancer covers more than 200 diseases, which are histologically and molecularly
… However, malignant transformation requires the destabilization of multiple signals, which …

… malignancies are characterized by high levels of expression … -IIA, previously known as
membrane-associated PLA2, or M-… It has been shown that sPLA2-IIA expression was increased …

… The phospholipase A2 (PLA2) superfamily comprises a spectrum of … PLA2’s role in different
malignancies is either as promoter or … PLA2 expression was also detected as enhanced in …

… Phospholipase A2 enzymes hydrolyze membrane phospholipids that are composed of a …
Thus, the increased expression and MAPK-mediated phosphorylation of cPLA 2 α upon …

… One such enzyme is phospholipases, PLA2, a membrane-associated enzyme family whose
… Thus, PLA2R1 inhibition increased cancer cell growth via enhanced expression of sPLA2, …

… and X show high expression and … phospholipase A2 activity, iPLA2s also exhibit
lysophospholipase and transacylase activity [13,102,103]. iPLA2β and iPLAγ are membrane-associated, …

… Several studies have shown that phospholipase A2 (PLA2) … expression of PLCγ1 corresponds
to increased expression of … of iPLA2 are the membrane-associated iPLA2γ and the cytosol-…

… Phospholipase A1 and phospholipase A2 cleave the acyl … selective phospholipase A1 (PS-PLA1),
membrane-associated … in tumors that show high expression of cytokeratins 5/17, which …

… Increased expression of PLA1A is associated with metastatic … two types of lipases
having phospholipase A2 (PLA2) and … : PLA1A, membrane-associated phosphatidic acid-selective …