… amiodarone-induced diffusely increased hepatic attenuation in computed tomography (CT)
of the abdomen and pelvis in an elderly patient taking oral amiodarone … phospholipidosis [4,5,…

… a patient who was receiving amiodarone for more than 2 years. … microabscesses of the liver
and died of progressive liver failure. … Amiodarone could induce lysosomal phospholipidosis, …

… like Amiodarone leads to development of phospholipidosis, a … Such disorder in liver enhances
accumulation of drugs and its … The increased phospholipidosis observed after the addition …

… liver injury (DILI) is a condition caused by drugs that leads to … of hepatotoxicity, such as
phospholipidosis, steatosis and … lead to hepatotoxicity, and it was confirmed that amiodarone, …

… is the morphological hallmark of amiodarone-induced liver injury. As with our patient,
phospholipidosis is identified by … When amiodarone-taking patients show elevated liver enzymes, …

… other than amiodarone that cause phospholipidosis. We … was more accurate in predicting
phospholipidosis compared … with pulmonary fibrosis, hepatic steatosis or steatohepatitis, …

… phospholipidosis in the liver organoids (Figure 9). The organoids treated with 10 μM amiodarone
… could obtain the liver tissues and establish normal liver organoids from more people, …

… Biochemical evaluation of AM-treated animal group showed a significant increase in cholesterol…
a significant increase of liver enzymes (ρ < 0.05) coupled with an obvious change in liver …

… as biomarkers for amiodarone-induced liver injury. Oral amiodarone administration for 1
week in rats resulted in significant elevation of acylcarnitines and phospholipids in the liver. …

… The IC 50 values for amiodarone and sertraline are … μmol/liter) which can accumulate up to
20-fold in the liver (32… IC 50 value is 10-fold higher than the plasma concentration achieved in …