… strictly associated with increased hepatic lipid deposition, … amiodarone administration,
intracytoplasmic lamellar bodies were found in the hepatocytes, representing phospholipidosis [42,…

… that it is related to drug deposition in the liver lysosomes, … The phospholipidosis can
begin as early as 2 months after … presence of liver damage amiodarone toxicity increases [29]. …

… in phospholipidosis and extended amiodarone accumulation. Amiodarone concentrations
in the liver … In conclusion, patients treated with amiodarone showed significantly higher liver …

… Another drug which increases BMP, Amiodarone 13 , has been … the liver that targets the
low density lipoprotein (LDL) receptor for degradation 14,15,16 . Deficiency of PCSK9 leads to …

… Biochemical analysis in the present study revealed increased TNF-α and HCy levels in
liver tissues of the AMD treated group (p ≤ 0.0001, p ≤ 0.001). Moreover, TF levels of the …

… more serious and common acute liver injury. It appears that some drugs, like amiodarone and
statins, do not induce hepatotoxicity more … phospholipidosis, despite years of amiodarone …

… causes amiodarone to have a major influence on the hepatic … effective concentrations of
amiodarone are innately more toxic than … bodies, signifying a mild degree of phospholipidosis. …

… to be related to drug toxicity [10] and in particular to liver and … amiodarone, there was a
concentration-dependent increase … fluoxetine, clozapine, and amiodarone, belonging to the CADs …

… serum amiodarone concentrations increase with increasing … and CLogP to predict
phospholipidosis-inducing potential: a … , hepatic and pulmonary uptake of posaconazole in rat. …

… The concomitant use of amiodarone increases the mean dose-… of direct cellular toxicity,
phospholipidosis, immune reactions, and … Amiodarone-related liver injury is considered to be an …