… without increasing hepatic fatty acid synthesis (224). Paradoxically, increased nuclear … -1c
(SREBP-1c) results in lipogenesis in the liver, through induction of LXR-α (225). In this …

… study of liver biology are one of either in vivo murine origin or in vitro cell culture models; …
in hepatic lysosomes which can progress to phospholipidosis - steatosis and eventual …

… More efforts were made in our lab to form mouse hepatocyte … with classical hepatotoxicants
such as amiodarone, bosentan, … , phospholipidosis (PLD) is another hepatic disorder with …

… Mitochondrial dysfunction induced by drugs, or more frequently by their reactive
metabolites, contributes to increased ROS formation and oxidative damage to liver cells. …

… For instance, the N-oxide of tamoxifen is formed in the liver due to increased CYP3A4 … -a-go-go
related gene (hERG) potassium channel or that induce phospholipidosis (PLD). As the …

… Consistent with previous studies (Jiang et al., 2016), our results showed that the body weight,
lipid contents, and liver enzymes in the serum of animals were increased in rats receiving …

… Liver produces physiological energy and degrades and excretes exogenous compounds.
It has a much higher mitochondrial density than most other organs. Liver can also synthesize …

… apoptosis and phospholipidosis are related and may share … metabolism include inhibition
of Liver X receptors (LXR) with … reviled an increase in phospholipidosis after incubation with 7…

… We found that ubiquitination of STX17 was increased and upregulation of seven in absentia
… liver disease, indicating a novel potential therapeutic target for fatty liver disease treatment. …

… amphiphilic drugs like, eg, amiodarone. These drugs have a … a storage disorder called
phospholipidosis. Furthermore, the … (prolonged QT-time or increase of liver enzymes), medical …