… 2004 that IL-23 promoting IL-17 production is linked to multiple … [6], suggesting a role
for the Th17 pathway in human diseases. … with moderate–severe psoriasis: ustekinumab (anti-IL-12/…

… Eight patients (5 with CD and 3 with UC) had been in remission by the time of inclusion in
this study; therefore, they fell in the mild or moderate disease severity category. Younger …

… In contrast, no significant difference was observed for the levels of IL-23 or its receptor
according to the disease severity or duration. Data were processed by nonparametric Mann-…

… interleukin 23 subunit α) and IL-23R (interleukin 23 receptor) in the development of psoriasis.
The study determined their expression … levels of IL-10 are not indicative of disease severity. …

… more severe inflammatory disease in one study.Genetic absence of IL-17A was also reported
to increase the severity of … made no difference or improved disease activity parameters and …

… , while IL-23Rα was commonly required. This observation challenges the current paradigm
… IL-12Rβ1 as a prerequisite to transmit IL-23 signaling. We hypothesized that p19/EBI3 (IL-39) …

… To calibrate NL luminescence and AF488 fluorescent intensity values in order to estimate
expression levels, we made up and measured a standard curve of both purified NL and SNAP…

… alone, both mice that received IL-23R-deficient Treg cells and mice that received WT Treg
cells exhibited a statistically significant improvement in disease severity based on histological …

… The Chinese keywords used were “IL-23R” and “rheumatoid arthritis” or “the Interleukin 23
… mice expressing P19 subunit of IL-23 developed more severe organ inflammation [29]. IL-23 …

… gene polymorphisms in the interleukin-23 receptor (IL23R) and interleukin 17A (IL17A…
diseases, severe liver and kidney disease, cardiovascular, cerebrovascular and endocrine disease…