… wide methylation profiles. We collected 3,644 samples that have both of mRNA and methylation
data from 12 major cancer types in The Cancer … As we have more samples available, our …

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… in cancer are mainly determined by their specialized functions. Our increased understanding
of epigenetic … to delay or reverse epigenetic modifications using the epigenetic clocks as a …

… promoter DNA hypermethylation of genes is the most frequent change when PCa is compared
to normal tissue [19, 22, 36, 37]. We also observed promoter DNA hypermethylation more …

… methylation across cancer types, and our results provide a valuable resource for both epigenetic
… Moreover, we found that the more the cancer types in which a MethTF was involved, the …

… of cancer cells and is due to genomic instability and epigenetic alterations [1]. The genomic
instability as increased … structural variations (aneuploidy and chromosome instability) [2]. The …

… Expression of histone deacetylases (HDACs) was reported to be increased in several cancer
types such as neuroblastoma and hepatocellular carcinomas [55]. The mode of action of …

… ” has itself undergone an evolution that parallels our dramatically increased knowledge
of the molecular mechanisms underlying regulation of gene expression in eukaryotes. Our …

… Although the role of epigenetic regulation and chromatin biology in cell differentiation and …
and development of cancer has recently been recognized with the increase of genomic data […