… cancer pathogenesis. In this review, we summarize the latest findings on DNA methylation
… , risk of relapse, treatment selection, and resistance, for breast, prostate, lung, and colorectal …

… This study showed that several hub genes contain one or more histone modification sites
responsible for Alzheimer's disease [9]. Hypermethylation at CpG islands results in the …

… biological process that increases the risk of multiple diseases including cancer. Growing …
cells and cancer cells. In this review, we detail the genetic and epigenetic changes associated …

… This study showed a clear association between the inactivation of MGMT by promoter
hypermethylation and an increase in the guanine to adenine mutations in K-Ras oncogenes [71]. …

… more focal gain of methylation observed in other gene loci, we observed differential methylation
… Our findings suggest that epigenetic silencing by CpG methylation contributes to PSMA …

… Gain-of-function mutations (E1099K and T1150A) in the SET domain of NSD2 have been
associated with the enhanced … Here, we explore each of these determinants in more detail: …

… We demonstrate increasing resolution and specificity ranging from protein complex, gene,
sub-gene, protein domain, and even single nucleotide-level Mendelian episignatures. We …

… —except for iPSCs, which resemble a ground state of non-differentiated cells—we identified
more hypomethylated than hypermethylated CpGs in our feature selection (Fig. 3a). One …

… Palbociclib and Ribociclib are two FDA-approved CDK4/6 inhibitors for cancer treatment.
One study showed that p16 INK4A methylation increased tumor sensitivity to the CDK4/6 …

… DNA methylation landscape across cancer types, none of these mutations are frequent across
… The fraction of CGIs in promoters decreased along with the elevated methylation across …