Acute symptomatic neonatal seizures, brain injury, and long-term outcome: the role of neuroprotective strategies
F Pisani, C Fusco, L Nagarajan… - Expert review of …, 2021 - Taylor & Francis
… severe HIE is associated with greater primary cerebral damage, earlier onset of secondary
deterioration, and greater neuronal loss, but also (as we discussed above) with more …
deterioration, and greater neuronal loss, but also (as we discussed above) with more …
[HTML][HTML] Biomolecular mechanisms of epileptic seizures and epilepsy: a review
KT Sumadewi, S Harkitasari, DC Tjandra - Acta Epileptologica, 2023 - Springer
… caused by a single gene mutation is benign familial newborn convulsions. These genetic …
The absence or inhibition of HCN1 channels increases neuronal hyperexcitability, seizure …
The absence or inhibition of HCN1 channels increases neuronal hyperexcitability, seizure …
Nuclear localization of NCX: Role in Ca2+ handling and pathophysiological implications
… In fact, increases in nuclear Ca 2+ levels may occur … of nuclear Ca 2+ levels occurring
in neurons after glutamate … proposed in in vivo model of epilepsy, since LIGA 20 reduced …
in neurons after glutamate … proposed in in vivo model of epilepsy, since LIGA 20 reduced …
The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice
J Smith, A Menéndez Méndez, M Alves… - British Journal of …, 2023 - Wiley Online Library
… Elevated neuroinflammatory markers, including interleukin-1β (IL-1β) and tumour necrosis
… models of neonatal seizures and in tissue from patients with elevated neuroinflammation …
… models of neonatal seizures and in tissue from patients with elevated neuroinflammation …
Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain
S Jung, YE Ballheimer, F Brackmann, D Zoglauer… - Brain research, 2020 - Elsevier
… were that neonatal seizures 1) … neurons in the CA3 and dentate gyrus region (Russo et al.,
2013). However, in agreement with our findings, more recent studies reported acute neuronal …
2013). However, in agreement with our findings, more recent studies reported acute neuronal …
[HTML][HTML] Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
PD Negraes, CA Trujillo, NK Yu, W Wu, H Yao… - Molecular …, 2021 - nature.com
… :EGFP to label neurons, into newborn mouse brains (… neurons are more excitable than
controls. This hyperexcitability of CDD cortical neurons could explain the occurrence of seizures …
controls. This hyperexcitability of CDD cortical neurons could explain the occurrence of seizures …
Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits
… These results indicate that the rescue of acute PB-resistant neonatal seizures using a
novel intervention positively modulates the long-term outcomes at P7 when the seizures are …
novel intervention positively modulates the long-term outcomes at P7 when the seizures are …
Calcium and activity-dependent signaling in the developing cerebral cortex
A Arjun McKinney, R Petrova… - Development, 2022 - journals.biologists.com
… Here, we focus on channels mediating two types of calcium entry in immature neural
cells that … -dependent Ca v 1.2 channel inactivation, resulting in elevated depolarization-induced …
cells that … -dependent Ca v 1.2 channel inactivation, resulting in elevated depolarization-induced …
[HTML][HTML] Metabolic seizures
M Almannai, RA Al Mahmoud, M Mekki… - Frontiers in …, 2021 - frontiersin.org
… neonatal seizures, refractory seizures, seizures related … seizures due to disrupting neuronal
circuits (8). It is worth mentioning that etiology of seizures in metabolic diseases can be more …
circuits (8). It is worth mentioning that etiology of seizures in metabolic diseases can be more …
Early-onset developmental and epileptic encephalopathies of infancy: an overview of the genetic basis and clinical features
… in self-limited familial neonatal epilepsy, which is characterized by focal clonic … is a nuclear
protein whose expression in the central nervous system overlaps with MeCP2 during neural …
protein whose expression in the central nervous system overlaps with MeCP2 during neural …