Modulation of posttraumatic epileptogenesis in aquaporin4 knockout mice

JI Szu, DD Patel, S Chaturvedi, JW Lovelace… - …, 2020 - Wiley Online Library
channel AQP4. Absence of AQP4 … lead to hippocampal SRSs and mice lacking AQP4
exhibited significantly longer seizure duration compared with WT mice. Future studies utilizing this …

[HTML][HTML] Mechanisms underlying aquaporin-4 subcellular mislocalization in epilepsy

JI Szu, DK Binder - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
… processes is the astrocyte water channel aquaporin-4 (AQP4). … mice lacking AQP4 exhibited
an increase in electrographic … On the other hand, the prolonged seizure duration may be …

Aquaporin-4 reduces post-traumatic seizure susceptibility by promoting astrocytic glial scar formation in mice

DC Lu, Z Zador, J Yao, F Fazlollahi… - Journal of …, 2021 - liebertpub.com
… The glial water channel, aquaporin-4 (AQP4), was shown to … to seizures is significantly
higher in mice lacking AQP4 in a … this 20-min period, and length of seizures was unrelated to …

Aquaporin-4 dysregulation in a controlled cortical impact injury model of posttraumatic epilepsy

JI Szu, S Chaturvedi, DD Patel, DK Binder - Neuroscience, 2020 - Elsevier
… Two key players are the astrocytic water channel aquaporin-4 (… The mean seizure duration
was analyzed with Kruskal–… was mostly preserved in injured mice without PTE suggesting a …

Aquaporin-4 inhibition attenuates Pentylenetetrazole-induced behavioral seizures and cognitive impairments in kindled rats

F Rostami, M Janahmadi, N Hosseinmardi - Physiology & Behavior, 2024 - Elsevier
… involved in regulating neural excitability is the astrocytic water channel aquaporin-4 [11,14]. …
clonic seizures in mice lacking AQP4. Moreover, the duration of stimulation-evoked seizures

The Role of Aquaporins in Epileptogenesis—A Systematic Review

L Bonosi, UE Benigno, S Musso, K Giardina… - International Journal of …, 2023 - mdpi.com
… threshold and duration. This was highlighted by … higher in the sclerotic hippocampus (CA1
region), suggesting the role of this water channel in the pathogenesis of intractable epilepsy

[PDF][PDF] Targeting aquaporin-4 subcellular localization to treat central nervous system edema

P Kitchen, MM Salman, AM Halsey, C Clarke-Bland… - Cell, 2020 - cell.com
water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water
… (DC+shControl), which had elevated spinal water content at 3 dpi and were still functionally …

Protective effects of aquaporin-4 deficiency on longer-term neurological outcomes in a mouse model

X Liu, Y Xie, X Wan, J Wu, Z Fan, L Yang - Neurochemical Research, 2021 - Springer
… that relies on the polarized water channel aquaporin-4 (AQP4) at … cut into sections with a
side length of 4 mm. And isometric … leads to convulsions and seizures. Neuroinflammation is an …

Aquaporin-4 deficiency is associated with cognitive impairment and alterations in astrocyte-neuron lactate shuttle

H Cha, JH Choi, H Jeon, JH Kim, M Kim, SJ Kim… - Molecular …, 2023 - Springer
Aquaporin-4 (AQP-4) is a water channel expressed in … We compared and analyzed the
length of stay, activity, and distance … In this study, we found that mice lacking AQP-4 showed …

Regulation of AQP4 in the central nervous system

A Vandebroek, M Yasui - International journal of molecular sciences, 2020 - mdpi.com
Aquaporin-4 (AQP4) is the main water channel protein … in cases of temporal lobe epilepsy
(TLE) via transcriptome … alone does not explain an increase in water permeability found in the …