β-Hydroxybutyrate Attenuates Painful Diabetic Neuropathy via Restoration of the Aquaporin-4 Polarity in the Spinal Glymphatic System

F Wang, C Xu, C Su, J Li, J Lin - Frontiers in neuroscience, 2022 - frontiersin.org
… system based on aquaporin-4 (AQP4) water channels on the … of AQP4 is more important
for water homeostasis than the … Most importantly, the duration of anesthesia in different rats

[HTML][HTML] Astrocyte-neuron circuits in epilepsy

BS Purnell, M Alves, D Boison - Neurobiology of disease, 2023 - Elsevier
… Red highlights seizures and the increased neuronal excitability … the FDA-approved Panx1
channel blockers probenecid or … from epilepsy patients and decreased seizures in a mouse

Acetazolamide alleviate cerebral edema induced by ischemic stroke through inhibiting the expression of AQP4 mRNA

JQ Hao, XY He, X Yang, YC Xiao, SQ Duan, H Wang… - Neurocritical Care, 2022 - Springer
… We want to investigate the effect of aquaporin-4 (AQP4) on … channel proteins that process
high permeability to water … [17] found that the activity of AQP4 increased in epilepsy, edema …

Dysregulation of ambient glutamate and glutamate receptors in epilepsy: an astrocytic perspective

OB Alcoreza, DC Patel, BP Tewari… - Frontiers in …, 2021 - frontiersin.org
… the bi-directional water channel, aquaporin-4, which are enriched … of the bi-directional water
channel, aquaporin-4 (AQP4), … elevated extracellular glutamate during seizures in epilepsy

Perspectives on the basis of seizure-induced respiratory dysfunction

DK Mulkey, BM Milla - Frontiers in Neural Circuits, 2022 - frontiersin.org
… uptake and resulted in increased seizure activity and premature … .1 channels also colocalize
with aquaporin-4 (Aqp4) water channels (Nagelhus et al., 2004) and Aqp4 knockout mice

Aquaporin inhibitors

S Wang, EI Solenov, B Yang - Aquaporins, 2023 - Springer
… And the glymphatic system, that is aquaporin 4 (AQP4) facilitated … Despite its association
with elevated seizure threshold … and increased threshold and prolonged duration of induced …

Aquaporin-4 protein expression in normal canine brains

P Álvarez, E Blasco, M Pumarola, A Wessmann - BMC veterinary research, 2021 - Springer
… ’s primary role as water channel protein and therefore might be more limited to regions of
actual fluid exchange, such as perivascular (blood), subpial and periventricular (CSF) areas. …

Animal models of metabolic epilepsy and epilepsy associated metabolic dysfunction: A systematic review

UP Kundap, YN Paudel, MF Shaikh - Pharmaceuticals, 2020 - mdpi.com
… associated with an increased risk of epilepsy development in … and clonic of frequent SE and
long duration [107]. The loss of … of Kcna1 is a voltage gated potassium channel subunit Kv1.1 …

Autoimmunity to ion channels in neurological diseases–Autoimmunity to aquaporin water channels

K Tanaka, A Nagaishi, M Matsui - Neurology and Clinical …, 2024 - Wiley Online Library
… of patients have autoantibodies against the aquaporin-4 (AQP4) water channel. In the central
… OAP was thought to increase water permeability, change cell–cell adhesion, and aid AQP4 …

The neurovascular unit dysfunction in the molecular mechanisms of epileptogenesis and targeted therapy

X Liu, Y Zhang, Y Zhao, Q Zhang, F Han - Neuroscience Bulletin, 2024 - Springer
… of epilepsy, we hope to pave the way for more effective … Aquaporin 4 (AQP4) is the most
abundantly expressed … and prolonged duration of seizures are observed in AQP4 knockout mice […