β-Hydroxybutyrate Attenuates Painful Diabetic Neuropathy via Restoration of the Aquaporin-4 Polarity in the Spinal Glymphatic System
F Wang, C Xu, C Su, J Li, J Lin - Frontiers in neuroscience, 2022 - frontiersin.org
… system based on aquaporin-4 (AQP4) water channels on the … of AQP4 is more important
for water homeostasis than the … Most importantly, the duration of anesthesia in different rats …
for water homeostasis than the … Most importantly, the duration of anesthesia in different rats …
[HTML][HTML] Astrocyte-neuron circuits in epilepsy
… Red highlights seizures and the increased neuronal excitability … the FDA-approved Panx1
channel blockers probenecid or … from epilepsy patients and decreased seizures in a mouse …
channel blockers probenecid or … from epilepsy patients and decreased seizures in a mouse …
Acetazolamide alleviate cerebral edema induced by ischemic stroke through inhibiting the expression of AQP4 mRNA
JQ Hao, XY He, X Yang, YC Xiao, SQ Duan, H Wang… - Neurocritical Care, 2022 - Springer
… We want to investigate the effect of aquaporin-4 (AQP4) on … channel proteins that process
high permeability to water … [17] found that the activity of AQP4 increased in epilepsy, edema …
high permeability to water … [17] found that the activity of AQP4 increased in epilepsy, edema …
Dysregulation of ambient glutamate and glutamate receptors in epilepsy: an astrocytic perspective
… the bi-directional water channel, aquaporin-4, which are enriched … of the bi-directional water
channel, aquaporin-4 (AQP4), … elevated extracellular glutamate during seizures in epilepsy …
channel, aquaporin-4 (AQP4), … elevated extracellular glutamate during seizures in epilepsy …
Perspectives on the basis of seizure-induced respiratory dysfunction
… uptake and resulted in increased seizure activity and premature … .1 channels also colocalize
with aquaporin-4 (Aqp4) water channels (Nagelhus et al., 2004) and Aqp4 knockout mice …
with aquaporin-4 (Aqp4) water channels (Nagelhus et al., 2004) and Aqp4 knockout mice …
Aquaporin inhibitors
S Wang, EI Solenov, B Yang - Aquaporins, 2023 - Springer
… And the glymphatic system, that is aquaporin 4 (AQP4) facilitated … Despite its association
with elevated seizure threshold … and increased threshold and prolonged duration of induced …
with elevated seizure threshold … and increased threshold and prolonged duration of induced …
Aquaporin-4 protein expression in normal canine brains
P Álvarez, E Blasco, M Pumarola, A Wessmann - BMC veterinary research, 2021 - Springer
… ’s primary role as water channel protein and therefore might be more limited to regions of
actual fluid exchange, such as perivascular (blood), subpial and periventricular (CSF) areas. …
actual fluid exchange, such as perivascular (blood), subpial and periventricular (CSF) areas. …
Animal models of metabolic epilepsy and epilepsy associated metabolic dysfunction: A systematic review
… associated with an increased risk of epilepsy development in … and clonic of frequent SE and
long duration [107]. The loss of … of Kcna1 is a voltage gated potassium channel subunit Kv1.1 …
long duration [107]. The loss of … of Kcna1 is a voltage gated potassium channel subunit Kv1.1 …
Autoimmunity to ion channels in neurological diseases–Autoimmunity to aquaporin water channels
K Tanaka, A Nagaishi, M Matsui - Neurology and Clinical …, 2024 - Wiley Online Library
… of patients have autoantibodies against the aquaporin-4 (AQP4) water channel. In the central
… OAP was thought to increase water permeability, change cell–cell adhesion, and aid AQP4 …
… OAP was thought to increase water permeability, change cell–cell adhesion, and aid AQP4 …
The neurovascular unit dysfunction in the molecular mechanisms of epileptogenesis and targeted therapy
X Liu, Y Zhang, Y Zhao, Q Zhang, F Han - Neuroscience Bulletin, 2024 - Springer
… of epilepsy, we hope to pave the way for more effective … Aquaporin 4 (AQP4) is the most
abundantly expressed … and prolonged duration of seizures are observed in AQP4 knockout mice […
abundantly expressed … and prolonged duration of seizures are observed in AQP4 knockout mice […