Improved Total Synthesis of Indolizidine and Quinolizidine Alkaloids via Nickel-Catalyzed (4+ 2) Cycloaddition

J Renner, SR Smith, JM Cowley… - The Journal of Organic …, 2022 - ACS Publications
A Ni-catalyzed (4 + 2) cycloaddition of bicyclic 3-azetidinones and alkynes was developed
to access indolizidine and quinolizidine alkaloids. A key element was the development of a …

One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds

Q Song, Y Liu, L Cai, X Cao, S Qian, Z Wang - Chinese Chemical Letters, 2021 - Elsevier
… Fused indolizidines and quinolizidines are important skeletons in a variety of natural … A
one-pot tandem route from amide to fused indolizidines and quinolizidines is disclosed. This …

Diastereodivergent Synthesis of the QuinolizidineIndolizidine Alkaloids of the Leontidine/Camoensine Family

S Wagner, S Sigl, M Schenkl… - European Journal of …, 2021 - Wiley Online Library
Leontidine and camoensine, the main representatives of the small quinolizidineindolizidine
alkaloid subgroup, are characterized by an inner bispidine system to which a 2‐pyridone …

Quinolizidine-type alkaloids: chemodiversity, occurrence, and bioactivity

W Cely-Veloza, MJ Kato, E Coy-Barrera - ACS omega, 2023 - ACS Publications
… The quinolizidine alkaloids (QAs) … quinolizidines, differentiating them from other alkaloids
derived from the l-lysine pathway, such as piperidine, indolizidine, and lycopodium alkaloids. (3…

Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids

NK Ratmanova, IA Andreev, AV Leontiev, D Momotova… - Tetrahedron, 2020 - Elsevier
… “Simple” indolizidines are alkaloids wherein bicyclic nucleus is not fused to other rings [[14], …
“Fused” indolizidines are represented by a number of classes of alkaloids, the most …

Total Synthesis of Indolizidine and Quinolizidine Alkaloids Via Ni-Catalyzed (4+ 2) Cycloaddition

J Renner - 2021 - search.proquest.com
… This fact raised immense interest in indolizidine and quinolizidine alkaloids, which have shown
… Chapter 1 reviews the biological activities of these alkaloids and represents the synthetic …

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

P Dey, A Kundu, A Kumar, M Gupta, BM Lee… - Recent advances in …, 2020 - Elsevier
… A fundamental understanding of the biological activity of important alkaloids is also
highlighted in this chapter. With the … True alkaloid Indolizidine alkaloids Quinolizidine alkaloids

Bioactive indolizidine alkaloids

SM Colegate, PR Dorling - Handbook of Plant and Fungal …, 2020 - taylorfrancis.com
… Recent studies on lupin alkaloids from Maackia tashiroi, a leguminous plant native to Japan…
several indolizidine compounds related to the more typical quinolizidine lupin alkaloids.4647 …

Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714

X He, J Ren, L Wang, J Luo, J Yang, YC Gu… - Organic …, 2023 - ACS Publications
… (1) In this study, we report the discovery of two new quinolizidine alkaloids, quinolizidomycins
A (1) and B (2) from Streptomyces sp. KIB-1714, and the putative biosynthetic pathway of …

The biological activities of quinolizidine alkaloids

J Zhang, YQ Liu, J Fang - The Alkaloids: Chemistry and Biology, 2023 - Elsevier
… Like indolizidine alkaloids, 78 a variety of quinolizidine alkaloids are insecticides since
they can inhibit phenylalanine tRNA binding to ribosomes.111, 112 These effects probably …