Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development

R Falcón-Moya, M Pérez-Rodríguez… - Nature …, 2020 - nature.com
… We also find that astrocytes are involved in the induction of … 1 adenosine receptors (A 1 Rs)
by adenosine from astrocytes, … Hence, it may be possible to control plasticity by manipulating

… -by-side comparison of the effects of Gq-and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal …

Y Van Den Herrewegen, TM Sanderson, S Sahu… - Molecular Brain, 2021 - Springer
… , induced consistent increases in spontaneous astrocytic Ca 2+ … -term chemogenetic
manipulation of astrocytes. a Timeline … in astrocytes induces activation of both glutamate receptors

Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms

Y Wang, AKY Fu, NY Ip - The FEBS Journal, 2022 - Wiley Online Library
… can precisely manipulate and monitor astrocytic signaling in … neuronal activity, astrocytic
CRAC channels induce the … purinergic and protease-activated receptors, which further triggers …

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

C Murphy-Royal, AD Johnston, AKJ Boyce… - Nature …, 2020 - nature.com
… expression of glucocorticoid receptors compared to neurons 9 . … stress modifies astrocyte
structure and function, inducing … we show that genetic manipulation of astrocytic gap junction …

Astrocytic cAMP modulates memory via synaptic plasticity

Z Zhou, K Okamoto, J Onodera… - Proceedings of the …, 2021 - National Acad Sciences
… Here, we show that an increase in astrocytic cAMP is sufficient to induce synaptic plasticity
activates NMDAR receptors and induces synaptic plasticity. By manipulating astrocytic cAMP, …

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Y Andrade-Talavera, A Fisahn… - Molecular …, 2023 - nature.com
… between synaptic and intrinsic plasticity induced by STDP, where … , astrocyte-mediated
plasticity is thought of as an activity-… Whether these manipulations adapt to, match, or drive a new …

Astrocytic IGF-IRs induce adenosine-mediated inhibitory downregulation and improve sensory discrimination

JA Noriega-Prieto, LE Maglio… - Journal of …, 2021 - Soc Neuroscience
… of astrocytes by IGF-I is essential for inducing Hebbian plasticity. … the barrel cortex induced
by the activation of astrocytic IGF-IRs … activity, we analyzed the effects of A 2A and A 1 receptor

An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning

K Bohmbach, N Masala, EM Schönhense, K Hill… - Nature …, 2022 - nature.com
… a role for synaptic long-term plasticity in vitro 6 and dendritic … used acute experimental
manipulations whenever possible because … if this stimulation protocol induces astrocytic activity

From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
… influence synapse formation, function, and plasticity. Beyond … current tools to selectively
manipulate astrocytes as well as … to the hindpaw induces cortical neuron gamma activity, thought …

The role of astrocyte‐mediated plasticity in neural circuit development and function

NA Perez-Catalan, CQ Doe, SD Ackerman - Neural development, 2021 - Springer
receptors is mediated by astrocyte-… neural activity, which can induce extensive, activity-dependent
functional and structural remodeling of mature synapses [79]. Also known as plasticity, …