… how age and malaria exposure influenced the induction of functional antibodies. We applied
… We previously found that complement-fixing activity by antibodies, a mechanism implicated …

… , complement-fixing antibodies were induced by RTS,S … RTS,S or develop new malaria
vaccines. Here we evaluated Fc-… functional antibody responses induced by RTS,S vaccination in …

… of functional complement fixing antibodies, and found a rapid decay after the final vaccine
dose… the induction and longevity of these cytophilic antibodies, particularly IgG3, may enhance …

… of functional antibodies and high complement-fixing activity as … antibody-mediated responses
elicited by the RTS, S malaria … vaccine effectiveness given the evidence of a low decay rate …

… RTS,S/AS01, the leading malaria vaccine, is currently under … the overall total IgG antibody
function against Plasmodium … half-life of RTS,S/AS02 induced complement-fixing antibodies is …

… which was associated with significantly enhanced affinity maturation of the vaccine-induced …
in antibody effector function, which may provide broader coverage and function that can …

… the immunodominant malaria vaccine epitope … functional antibody responses should be
assessed, and these results integrated with cellular data to address memory responses induced …

… induction of functional antibodies. There was a marked decay in functional complementfixing
antibodies … RTS is the first malaria vaccine to be in phase III clinical trials. In these trials it …

… The role of other antibody isotypes that could also contribute to vaccine efficacy remains …
RTS,S/AS01 E elicits antigen-specific serum IgA antibodies to the vaccine and other malaria …

… months post-vaccination, followed by a slower decay over the … IgG1 and IgG3 possess the
greatest complement-fixing ability… IgM function and protection in both pre-erythrocytic vaccine-…