Estradiol as the trigger of sirtuin-1-dependent cell signaling with a potential utility in anti-aging therapies

K Karolczak, C Watala - International Journal of Molecular Sciences, 2023 - mdpi.com
inducing a highly mitotic state and resistance to apoptosis, with … was effectively prevented
by resveratrol. Maintaining the correct … The consequences of sepsis-associated cell death are …

Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer: a review

JY Jang, E Im, ND Kim - International journal of molecular sciences, 2022 - mdpi.com
induce the formation of the death-inducing signalingresveratrol causes chondrosarcoma
cell apoptosis through SIRT1-activated NF-κB deacetylation and shows anti-chondrosarcoma

Resveratrol as an enhancer of apoptosis in cancer: a mechanistic review

M Ashrafizadeh, S Taeb… - … -Cancer Agents in …, 2021 - ingentaconnect.com
… different cancer cell lines has confirmed that resveratrol induces apoptosis through different
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis

Sirtuin insights: bridging the gap between cellular processes and therapeutic applications

S Kamal, S Babar, W Ali, K Rehman, A Hussain… - Naunyn-Schmiedeberg's …, 2024 - Springer
cells heavily depend on mitochondrial cell signaling for their proliferation, development,
and the disruption of metabolic pathways leading to heightened the mitochondrial apoptosis

Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis

J Suh, H Kim, J Min, HJ Yeon, M Hemberg… - Cell Reports …, 2024 - cell.com
… and sensitizes chondrosarcoma cells to doxorubicin-induced … In contrast, the PLA signal
was highly present in SW1353 … proliferation and enhanced apoptosis within the transplanted …

Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism

A Brockmueller, S Sameri, A Liskova, K Zhai… - Cancers, 2021 - mdpi.com
… , resveratrol-induced ER-stress leads to apoptosis of … resveratrol is the molecular signaling
pathway dependent on sirtuins (histone deacetylases) [168]. Resveratrol upregulates sirtuin 1

[HTML][HTML] Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes

S Chen, N Tamaki, Y Kudo, T Tsunematsu… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
… Nrf2 signaling and inhibiting NF-κB signaling, respectively. … (2) 5-FU blocks DNA replication
and induces the … and activity of Nrf2, suppresses apoptosis and resistance to oxidative stress. …

Epigenetic Abnormalities in Chondrosarcoma

M Bereza, M Dembiński, AE Zając, J Piątkowski… - International Journal of …, 2023 - mdpi.com
… mTOR signaling pathway led to the progression of CS cells … ability of resveratrol was confirmed
in vivo by using a CS cell … the cell cycle [92], was observed to induce apoptosis and cell

Targeting Sirtuin 1 signaling pathway by ginsenosides

T Lou, Q Huang, H Su, D Zhao, X Li - Journal of Ethnopharmacology, 2021 - Elsevier
… Additionally, in cobalt chloride-induced PC12 cells and cerebral I/R injured rat models, …
SIRT1 signaling pathways, which may be related by the inhibitions of ROS generation, apoptosis, …

Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway

S Ghafouri-Fard, Z Bahroudi, H Shoorei… - Cancer Cell …, 2022 - Springer
… Besides, resveratrol has increased the expression of sirtuin 1 … In ovarian cancer cells,
resveratrol can induce apoptosis and … Moreover, resveratrol has been shown to induce cell death