Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - … and Targeted Therapy, 2023 - nature.com
Immunosenescence of neutrophils occurs in a low-grade inflammatory environment, with
specific abnormalities in their metabolism and function, including decreased phagocytic …

Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
neutrophils; this critically perpetuates the pro-inflammatory responses [64, 65]. Classically
activated macrophages are professional antigen-presenting cells (APCs) that can stimulate T-…

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

A Santoro, E Bientinesi, D Monti - Ageing Research Reviews, 2021 - Elsevier
… , immunosenescence has been considered detrimental because it may lead to a low-grade,
sterile chronic inflammation … The aged neutrophils (CD10 neg ) are accumulated in the skin …

Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
… to significant pro-inflammatory signalling and highlight the … immunosenescence, and
inflammation in driving poor health … and neutrophils, reduced levels of the most pro-inflammatory

Immunosenescence: molecular mechanisms and diseases

Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - … and targeted therapy, 2023 - nature.com
… This chronic inflammation is a typical phenomenon linked to immunosenescence and it is
considered the major … Age-regulated tissue-specific macrophages and neutrophils may cause …

Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions

A Salminen - Journal of Molecular Medicine, 2021 - Springer
immunosenescence, the occurrence of immunosenescent cells increases in many age-related
diseases … -grade chronic inflammation most probably promotes immunosenescence with …

Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients

I Maté, IM de Toda, L Arranz, JL Álvarez-Sala… - Experimental …, 2021 - Elsevier
… Thus, the purpose of the present work was to investigate several functions of circulating
neutrophils (adherence, chemotaxis, phagocytosis and superoxide anion stimulation capacity) …

How can we improve vaccination response in old people? Part I: Targeting immunosenescence of innate immunity cells

A Aiello, ME Ligotti, M Garnica, G Accardi… - International Journal of …, 2022 - mdpi.com
… This, in turn, reduces the ability of neutrophils to survive longer at the site of inflammation, …
across disease states. It has been suggested that altered functions may represent neutrophil “…

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the …

F Roth‐Walter, IM Adcock, C Benito‐Villalvilla… - Allergy, 2024 - Wiley Online Library
inflammatory lung diseases. … inflammation on immune cells and tissue microenvironment
are thus chiefly involved in the pathophysiology of allergic and other immune‐driven diseases. …

[HTML][HTML] Immunosenescence and inflamm-aging: clinical interventions and the potential for reversal of aging

SJ Kumar, S Shukla, S Kumar, P Mishra - Cureus, 2024 - ncbi.nlm.nih.gov
… , and, hence, the hallmarks of immunosenescence may be markedly and … Inflammation is
a key component of immunosenescence, … Dysfunction of neutrophils and macrophages as a …